PMID- 10475192
OWN - NLM
STAT- MEDLINE
DCOM- 19990921
LR  - 20151119
IS  - 0140-6736 (Print)
IS  - 0140-6736 (Linking)
VI  - 354
IP  - 9180
DP  - 1999 Aug 28
TI  - Cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphism confers
      susceptibility to thyroid associated orbitopathy.
PG  - 743-4
AB  - Smoking and demographic variables are known to be risk factors for the
      development of thyroid-associated orbitopathy (TAO) among patients with Graves'
      hyperthyroidism, but a firm genetic basis for TAO has not been established. We
      show that the presence and severity of TAO are associated with an allele of the
      cytotoxic T lymphocyte antigen-4-gene.
FAU - Vaidya, B
AU  - Vaidya B
FAU - Imrie, H
AU  - Imrie H
FAU - Perros, P
AU  - Perros P
FAU - Dickinson, J
AU  - Dickinson J
FAU - McCarthy, M I
AU  - McCarthy MI
FAU - Kendall-Taylor, P
AU  - Kendall-Taylor P
FAU - Pearce, S H
AU  - Pearce SH
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Letter
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Lancet
JT  - Lancet (London, England)
JID - 2985213R
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Differentiation)
RN  - 0 (CTLA-4 Antigen)
RN  - 0 (CTLA4 protein, human)
RN  - 0 (Genetic Markers)
RN  - 0 (Immunoconjugates)
RN  - 7D0YB67S97 (Abatacept)
SB  - IM
CIN - Lancet. 1999 Nov 20;354(9192):1824. PMID: 10577673
MH  - Abatacept
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Antigens, CD
MH  - Antigens, Differentiation/*genetics
MH  - CTLA-4 Antigen
MH  - Child
MH  - Female
MH  - Genetic Markers/genetics
MH  - Genetic Predisposition to Disease/*genetics
MH  - Graves Disease/*genetics/immunology
MH  - Humans
MH  - *Immunoconjugates
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic/*genetics
MH  - Risk Factors
MH  - T-Lymphocytes, Cytotoxic/*immunology
EDAT- 1999/09/04 09:00
MHDA- 2000/02/19 09:00
CRDT- 1999/09/04 09:00
PHST- 1999/09/04 09:00 [pubmed]
PHST- 2000/02/19 09:00 [medline]
PHST- 1999/09/04 09:00 [entrez]
AID - S0140-6736(99)01465-8 [pii]
AID - 10.1016/S0140-6736(99)01465-8 [doi]
PST - ppublish
SO  - Lancet. 1999 Aug 28;354(9180):743-4. doi: 10.1016/S0140-6736(99)01465-8.