PMID- 10474040
OWN - NLM
STAT- MEDLINE
DCOM- 19991007
LR  - 20171101
IS  - 1018-1172 (Print)
IS  - 1018-1172 (Linking)
VI  - 36
IP  - 4
DP  - 1999 Jul-Aug
TI  - Expression of tie1 and tie2 proteins during reendothelialization in
      balloon-injured rat carotid artery.
PG  - 272-81
AB  - The novel endothelial cell tyrosine kinase receptors, Tie1 and Tie2, are
      essential for vascular development and remodeling in the embryo but little is
      known regarding the regulation of their expression and their role in the
      maintenance and repair of the adult vascular system. We examined the expression
      of Tie1 and Tie2 in normal vessels and during reendothelialization following
      balloon injury of the adult rat carotid artery. Tie proteins were detected in
      quiescent endothelial cells of the adult rat carotid artery. Tie1 and Tie2
      proteins were also detected in human and rat platelets. A weak expression of Tie1
      and Tie2 proteins was detected in young endothelial cells which sparsely
      repopulated the denuded surface by day 14. Protein levels increased in the
      confluent layer of endothelial cells by day 28. Based on these observations, we
      tested whether Tie1 and Tie2 mRNA and protein levels are regulated by cell
      density. Tie1 and Tie2 expression significantly increased with higher density in 
      cultured human endothelial cells, and this upregulation required cell-cell
      interaction. These data suggest that Tie1 and Tie2 may play a role in the
      maintenance and repair of the adult vascular system and that the expression of
      these proteins is regulated by cell density.
FAU - Fujikawa, K
AU  - Fujikawa K
AD  - Department of Medicine, Division of Hematology/Oncology and Cardiovascular
      Research, St. Elizabeth's Medical Center, Tufts University School of Medicine,
      Boston, Mass. 02135, USA.
FAU - Presman, E
AU  - Presman E
FAU - Isner, J M
AU  - Isner JM
FAU - Varticovski, L
AU  - Varticovski L
LA  - eng
GR  - R01 NIH-967031/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Switzerland
TA  - J Vasc Res
JT  - Journal of vascular research
JID - 9206092
RN  - 0 (Receptors, Cell Surface)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Receptor, TIE-1)
RN  - EC 2.7.10.1 (Receptors, TIE)
SB  - IM
EIN - J Vasc Res 1999 Nov-Dec;36(6):509
MH  - Angioplasty, Balloon/*adverse effects
MH  - Animals
MH  - Carotid Arteries/innervation/*metabolism
MH  - Cells, Cultured
MH  - Endothelium, Vascular/*physiology
MH  - Humans
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor Protein-Tyrosine Kinases/*analysis
MH  - Receptor, TIE-1
MH  - Receptors, Cell Surface/*analysis
MH  - Receptors, TIE
MH  - *Regeneration
EDAT- 1999/09/04 09:00
MHDA- 2000/02/19 09:00
CRDT- 1999/09/04 09:00
PHST- 1999/09/04 09:00 [pubmed]
PHST- 2000/02/19 09:00 [medline]
PHST- 1999/09/04 09:00 [entrez]
AID - 25655 [pii]
AID - 10.1159/000025655 [doi]
PST - ppublish
SO  - J Vasc Res. 1999 Jul-Aug;36(4):272-81. doi: 10.1159/000025655.