PMID- 10473130
OWN - NLM
STAT- MEDLINE
DCOM- 19991012
LR  - 20190910
IS  - 0925-4773 (Print)
IS  - 0925-4773 (Linking)
VI  - 84
IP  - 1-2
DP  - 1999 Jun
TI  - Dynamic expression of TSC-22 at sites of epithelial-mesenchymal interactions
      during mouse development.
PG  - 147-51
AB  - The leucine zipper transcription factor TSC-22 (TGF-beta1 Stimulated Clone-22)
      was first isolated from a mouse osteoblast cell line as an immediate-early target
      gene of TGF-beta1. However, work with other cell lines, as well as with a
      Drosophila homolog, bunched, suggests that it is an effector gene of various
      growth factors and potentially involved in the integration of multiple
      extracellular signals. Throughout mouse embryogenesis TSC-22 is expressed in a
      dynamic pattern. Although early TSC-22 expression is ubiquitous in 6.5 day
      embryos, as development proceeds TSC-22 expression is upregulated at sites of
      epithelial-mesenchymal interactions such as the limb bud, tooth primordiurn, hair
      follicle, kidney, lung, and pancreas. TSC-22 is also expressed in many neural
      crest-derived tissues including the mesenchyme of the branchial arches, the
      cranial, dorsal root, and sympathetic ganglia, as well as the facial cartilage
      and bone. Other areas of expression are the otic and optic vesicles, the heart,
      and cartilage and bone forming regions throughout the embryo.
FAU - Dohrmann, C E
AU  - Dohrmann CE
AD  - Cutaneous Biology Research Center, Massachusetts General Hospital/Harvard Medical
      School, Charlestown 02129, USA.
FAU - Belaoussoff, M
AU  - Belaoussoff M
FAU - Raftery, L A
AU  - Raftery LA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Mech Dev
JT  - Mechanisms of development
JID - 9101218
RN  - 0 (Repressor Proteins)
RN  - 0 (Tgfb1i4 protein, mouse)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - Brain/embryology/metabolism
MH  - Epithelium/embryology/metabolism
MH  - Eye/embryology/metabolism
MH  - Ganglia/embryology/metabolism
MH  - *Gene Expression Regulation, Developmental
MH  - In Situ Hybridization/methods
MH  - Leucine Zippers/genetics
MH  - Limb Buds/metabolism
MH  - Mesoderm/*metabolism
MH  - Mice
MH  - *Repressor Proteins
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Transcription Factors/*genetics/*metabolism
EDAT- 1999/09/03 00:00
MHDA- 1999/09/03 00:01
CRDT- 1999/09/03 00:00
PHST- 1999/09/03 00:00 [pubmed]
PHST- 1999/09/03 00:01 [medline]
PHST- 1999/09/03 00:00 [entrez]
AID - S0925-4773(99)00055-6 [pii]
AID - 10.1016/s0925-4773(99)00055-6 [doi]
PST - ppublish
SO  - Mech Dev. 1999 Jun;84(1-2):147-51. doi: 10.1016/s0925-4773(99)00055-6.