PMID- 10473127 OWN - NLM STAT- MEDLINE DCOM- 19991012 LR - 20220129 IS - 0925-4773 (Print) IS - 0925-4773 (Linking) VI - 84 IP - 1-2 DP - 1999 Jun TI - Expression pattern of the Tbr2 (Eomesodermin) gene during mouse and chick brain development. PG - 133-8 AB - The members of the T-box gene family share a highly conserved DNA binding domain named the T-domain, and important developmental functions. Here we report the cloning of chicken Tbr1 and of murine and chicken Tbr2 (orthologs of the Xenopus eomesodermin gene), the mapping of the murine Tbr2 to chromosome 9, and their pattern of expression during mouse and chick embryogenesis. Both Tbr 1 and 2 have a restricted and conserved domain of expression in the telencephalic pallium of the two species. Chick Tbr2 has a specific and dynamic expression in the gastrulating embryo. FAU - Bulfone, A AU - Bulfone A AD - Telethon Institute of Genetics and Medicine (TIGEM), San Raffaele Biomedical Science Park, Milan, Italy. bulfone@tigem.it FAU - Martinez, S AU - Martinez S FAU - Marigo, V AU - Marigo V FAU - Campanella, M AU - Campanella M FAU - Basile, A AU - Basile A FAU - Quaderi, N AU - Quaderi N FAU - Gattuso, C AU - Gattuso C FAU - Rubenstein, J L AU - Rubenstein JL FAU - Ballabio, A AU - Ballabio A LA - eng GR - TGM06S01/TI_/Telethon/Italy GR - TGM97000/TI_/Telethon/Italy GR - NS34661-01A1/NS/NINDS NIH HHS/United States PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, P.H.S. PL - Ireland TA - Mech Dev JT - Mechanisms of development JID - 9101218 RN - 0 (DNA-Binding Proteins) RN - 0 (Eomes protein, mouse) RN - 0 (Nerve Tissue Proteins) RN - 0 (T-Box Domain Proteins) RN - 0 (Tbr1 protein, mouse) RN - 0 (Transcription Factors) SB - IM MH - Amino Acid Sequence MH - Animals MH - Brain/*embryology/growth & development/metabolism MH - Chick Embryo MH - Chickens MH - Chromosome Mapping MH - Cloning, Molecular MH - DNA-Binding Proteins/*genetics/metabolism MH - *Gene Expression Regulation, Developmental MH - Mice MH - Mice, Inbred C57BL MH - Molecular Sequence Data MH - *Nerve Tissue Proteins MH - Sequence Homology, Amino Acid MH - *T-Box Domain Proteins MH - Transcription Factors/genetics EDAT- 1999/09/03 00:00 MHDA- 1999/09/03 00:01 CRDT- 1999/09/03 00:00 PHST- 1999/09/03 00:00 [pubmed] PHST- 1999/09/03 00:01 [medline] PHST- 1999/09/03 00:00 [entrez] AID - S0925-4773(99)00053-2 [pii] AID - 10.1016/s0925-4773(99)00053-2 [doi] PST - ppublish SO - Mech Dev. 1999 Jun;84(1-2):133-8. doi: 10.1016/s0925-4773(99)00053-2.