PMID- 10473125
OWN - NLM
STAT- MEDLINE
DCOM- 19991012
LR  - 20190910
IS  - 0925-4773 (Print)
IS  - 0925-4773 (Linking)
VI  - 84
IP  - 1-2
DP  - 1999 Jun
TI  - Developmental expression analysis of murine autotaxin (ATX).
PG  - 121-5
AB  - The murine homologue of the human motility-stimulating protein autotaxin (ATX)
      was identified as a BMP2 upregulated gene by subtractive cloning from mesenchymal
      progenitors C3H10T1/2 (Bachner, D., Ahrens, M., Betat, N., Schroder, D.,
      Hoffmann. A., Lauber, J., Steinert, P., Flohe, L., Gross, G., 1998. Bmp-2
      downstream targets in mesenchymal development identified by subtractive cloning
      from recombinant mesenchymal progenitors (C3H10T1/2). Dev. Dyn. 213, 398-411).
      ATX mRNA transcription is induced during BMP2 mediated osteo-/chondrogenic
      differentiation in vitro several orders of magnitude. To delineate a potential
      role for ATX in osteo-/chondrogenic development, its expression pattern during
      murine embryogenesis was examined in comparison with Col1a1 and Col2a1, a marker 
      either of osteoblast, odontoblast and tendon or of chondrocyte development,
      respectively. Localization of murine ATX was first observed in the floor plate of
      the neural tube at day 9.5 of mouse embryonic development. Later, enhanced ATX
      expression levels were observed in proliferating subepithelial mesenchyme, during
      osteo-/chondrogenic and tooth development, in choroid plexus epithelium, in late 
      kidney development, and in smooth muscles of the ductus deferens and the bladder.
FAU - Bachner, D
AU  - Bachner D
AD  - Institute of Cellbiochemistry and Clinical Neurobiology, University Clinic
      Eppendorf, Hamburg, Germany.
FAU - Ahrens, M
AU  - Ahrens M
FAU - Betat, N
AU  - Betat N
FAU - Schroder, D
AU  - Schroder D
FAU - Gross, G
AU  - Gross G
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Mech Dev
JT  - Mechanisms of development
JID - 9101218
RN  - 0 (Glycoproteins)
RN  - 0 (Multienzyme Complexes)
RN  - 9007-34-5 (Collagen)
RN  - EC 3.1.4.- (Phosphoric Diester Hydrolases)
RN  - EC 3.1.4.1 (Phosphodiesterase I)
RN  - EC 3.1.4.39 (alkylglycerophosphoethanolamine phosphodiesterase)
RN  - EC 3.6.1.- (Pyrophosphatases)
RN  - EC 5.3.1.9 (Glucose-6-Phosphate Isomerase)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Bone and Bones/embryology/metabolism
MH  - Branchial Region/embryology/metabolism
MH  - Collagen/genetics/metabolism
MH  - Embryo, Mammalian/metabolism
MH  - *Gene Expression Regulation, Developmental
MH  - Glucose-6-Phosphate Isomerase/*genetics/metabolism
MH  - Glycoproteins/*genetics/metabolism
MH  - Humans
MH  - Kidney/embryology/metabolism
MH  - Limb Buds/metabolism
MH  - Mesoderm/metabolism
MH  - Mice
MH  - Mice, Inbred Strains
MH  - *Multienzyme Complexes
MH  - Phosphodiesterase I
MH  - Phosphoric Diester Hydrolases
MH  - Pyrophosphatases
MH  - Tooth/embryology/metabolism
EDAT- 1999/09/03 00:00
MHDA- 1999/09/03 00:01
CRDT- 1999/09/03 00:00
PHST- 1999/09/03 00:00 [pubmed]
PHST- 1999/09/03 00:01 [medline]
PHST- 1999/09/03 00:00 [entrez]
AID - S0925-4773(99)00048-9 [pii]
AID - 10.1016/s0925-4773(99)00048-9 [doi]
PST - ppublish
SO  - Mech Dev. 1999 Jun;84(1-2):121-5. doi: 10.1016/s0925-4773(99)00048-9.