PMID- 10473118
OWN - NLM
STAT- MEDLINE
DCOM- 19991012
LR  - 20190910
IS  - 0925-4773 (Print)
IS  - 0925-4773 (Linking)
VI  - 84
IP  - 1-2
DP  - 1999 Jun
TI  - Six6 (Optx2) is a novel murine Six3-related homeobox gene that demarcates the
      presumptive pituitary/hypothalamic axis and the ventral optic stalk.
PG  - 31-40
AB  - We report on the isolation of a murine homeobox-containing gene, Six6 (Optx2),
      that shows extended identity in its coding region with Six3, the only member of
      the mammalian Six gene family known to be expressed in the optic primordium.
      Phylogenetic analysis demonstrates that Six6 and Six3 belong to a separate group 
      of homeobox-genes that are closely related to the recently identified Drosophila 
      optix. Earliest Six6 expression was detected in the floor of the diencephalic
      portion of the primitive forebrain, a region predicted to give rise to the
      neurohypophysis and to the hypothalamus. Later on, Six6 mRNA was found in the
      primordial tissues giving rise to the mature pituitary: the Rathke's pouch and
      the infundibular recess. In the optic primordium, Six6 demarcates the presumptive
      ventral optic stalk and the ventral portion of the future neural retina. In the
      developing eye. Six6 expression was detected in the neural retina, the optic
      chiasma and optic stalk, but not in the lens. When compared to Six6, Six3
      expression pattern was highly similar, but with a generally broader transcripts
      distribution in the brain and in the visual system. We finally show that Six6
      does not require Pax6 for its expression in the optic primordium, suggesting that
      Six6 acts on a parallel and/or independent pathway with Pax6 in the genetic
      cascade governing early development of the eye.
FAU - Jean, D
AU  - Jean D
AD  - Max Planck Institute of Biophysical Chemistry, Department of Molecular Cell
      Biology, Gottingen, Germany.
FAU - Bernier, G
AU  - Bernier G
FAU - Gruss, P
AU  - Gruss P
LA  - eng
SI  - GENBANK/AF135267
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Mech Dev
JT  - Mechanisms of development
JID - 9101218
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Eye Proteins)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (PAX6 Transcription Factor)
RN  - 0 (Paired Box Transcription Factors)
RN  - 0 (Pax6 protein, mouse)
RN  - 0 (Repressor Proteins)
RN  - 0 (Sine oculis homeobox homolog 3 protein)
RN  - 0 (Six6 protein, mouse)
RN  - 0 (Trans-Activators)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Cloning, Molecular
MH  - DNA-Binding Proteins/genetics
MH  - Eye Proteins/genetics/metabolism
MH  - Homeodomain Proteins/*genetics/metabolism
MH  - Hypothalamus/*embryology/metabolism
MH  - Mice
MH  - Mice, Mutant Strains
MH  - Molecular Sequence Data
MH  - Mutation
MH  - Nerve Tissue Proteins/genetics
MH  - Optic Chiasm/*embryology/metabolism
MH  - PAX6 Transcription Factor
MH  - Paired Box Transcription Factors
MH  - Phylogeny
MH  - Pituitary Gland/*embryology/metabolism
MH  - Repressor Proteins
MH  - Retina/embryology/metabolism
MH  - Sequence Homology, Amino Acid
MH  - Trans-Activators/*genetics/metabolism
MH  - Visual Cortex/embryology/metabolism
EDAT- 1999/09/03 00:00
MHDA- 1999/09/03 00:01
CRDT- 1999/09/03 00:00
PHST- 1999/09/03 00:00 [pubmed]
PHST- 1999/09/03 00:01 [medline]
PHST- 1999/09/03 00:00 [entrez]
AID - S0925-4773(99)00068-4 [pii]
AID - 10.1016/s0925-4773(99)00068-4 [doi]
PST - ppublish
SO  - Mech Dev. 1999 Jun;84(1-2):31-40. doi: 10.1016/s0925-4773(99)00068-4.