PMID- 10471835
OWN - NLM
STAT- MEDLINE
DCOM- 19991012
LR  - 20191210
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 457
IP  - 3
DP  - 1999 Sep 3
TI  - Dissociation of the eukaryotic initiation factor-4E/4E-BP1 complex involves
      phosphorylation of 4E-BP1 by an mTOR-associated kinase.
PG  - 489-93
AB  - mTOR immunoprecipitates contain two 4E-BP1 protein kinase activities. One appears
      to be due to mTOR itself and results in the phosphorylation of 4E-BP1 on residues
      T(36) and T(45), as shown previously by others. The other is a kinase which can
      be separated from mTOR and which phosphorylates 4E-BP1 within a peptide(s)
      containing residues S(64) and T(69). This phosphorylation, which occurs
      predominantly on S(64), results in the dissociation of 4E-BP1 from eIF-4E.
FAU - Heesom, K J
AU  - Heesom KJ
AD  - Department of Biochemistry, School of Medical Sciences, University Walk, Bristol,
      UK. k.heesom@bris.ac.uk
FAU - Denton, R M
AU  - Denton RM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Carrier Proteins)
RN  - 0 (Eif4ebp1 protein, rat)
RN  - 0 (Eukaryotic Initiation Factor-4E)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Peptide Initiation Factors)
RN  - 0 (Phosphoproteins)
RN  - 0 (Recombinant Proteins)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.1.- (Phosphotransferases (Alcohol Group Acceptor))
RN  - EC 2.7.1.1 (TOR Serine-Threonine Kinases)
RN  - EC 2.7.1.1 (mTOR protein, rat)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - *Carrier Proteins
MH  - Eukaryotic Initiation Factor-4E
MH  - Intracellular Signaling Peptides and Proteins
MH  - Male
MH  - Molecular Sequence Data
MH  - Peptide Initiation Factors/genetics/immunology/*metabolism
MH  - Phosphoproteins/genetics/immunology/*metabolism
MH  - Phosphorylation
MH  - Phosphotransferases (Alcohol Group Acceptor)/isolation & purification/*metabolism
MH  - Precipitin Tests
MH  - Protein Kinases/immunology/isolation & purification/*metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Recombinant Proteins/genetics/metabolism
MH  - TOR Serine-Threonine Kinases
EDAT- 1999/09/03 00:00
MHDA- 1999/09/03 00:01
CRDT- 1999/09/03 00:00
PHST- 1999/09/03 00:00 [pubmed]
PHST- 1999/09/03 00:01 [medline]
PHST- 1999/09/03 00:00 [entrez]
AID - S0014-5793(99)01094-7 [pii]
AID - 10.1016/s0014-5793(99)01094-7 [doi]
PST - ppublish
SO  - FEBS Lett. 1999 Sep 3;457(3):489-93. doi: 10.1016/s0014-5793(99)01094-7.