PMID- 10471813
OWN - NLM
STAT- MEDLINE
DCOM- 19991012
LR  - 20190621
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 457
IP  - 3
DP  - 1999 Sep 3
TI  - A novel Jun N-terminal kinase (JNK)-binding protein that enhances the activation 
      of JNK by MEK kinase 1 and TGF-beta-activated kinase 1.
PG  - 385-8
AB  - We have identified a novel Jun N-terminal kinase (JNK)-binding protein, termed
      JNKBP1, and examined its binding affinity for JNK1, JNK2, JNK3, and extracellular
      signal-regulated kinase 2 (ERK2) in COS-7 cells. JNKBP1 preferentially interacted
      with the JNKs, but not with ERK2. Furthermore, we investigated the effect of
      overexpressing JNKBP1 on the JNK and ERK signaling pathways in COS-7 cells.
      JNKBP1 alone had only a marginal effect on JNK activity. However, the activation 
      of JNK by MEK kinase 1 and TGF-beta-activated kinase 1 was significantly enhanced
      in the presence of JNKBP1. In contrast, JNKBP1 had no or very little effect on
      the ERK signaling pathway. These results suggest that JNKBP1 functions to
      facilitate the specific and efficient activation of the JNK signaling pathways.
FAU - Koyano, S
AU  - Koyano S
AD  - Department of Biosciences, School of Science, Kitasato University, 1-15-1
      Kitasato, Kanagawa, Japan.
FAU - Ito, M
AU  - Ito M
FAU - Takamatsu, N
AU  - Takamatsu N
FAU - Shiba, T
AU  - Shiba T
FAU - Yamamoto, K
AU  - Yamamoto K
FAU - Yoshioka, K
AU  - Yoshioka K
LA  - eng
SI  - GENBANK/AB029482
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Carrier Proteins)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Mapkbp1 protein, mouse)
RN  - 0 (Recombinant Proteins)
RN  - EC 2.7.11.1 (Protein-Serine-Threonine Kinases)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinases)
RN  - EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 1)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
RN  - EC 2.7.11.25 (MAP Kinase Kinase Kinase 1)
RN  - EC 2.7.11.25 (MAP Kinase Kinase Kinases)
RN  - EC 2.7.11.25 (MAP kinase kinase kinase 7)
RN  - EC 2.7.11.25 (Map3k1 protein, mouse)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Binding Sites
MH  - COS Cells
MH  - Calcium-Calmodulin-Dependent Protein Kinases/*metabolism
MH  - Carrier Proteins/*genetics/*metabolism
MH  - Cloning, Molecular
MH  - Hybrid Cells
MH  - *Intracellular Signaling Peptides and Proteins
MH  - JNK Mitogen-Activated Protein Kinases
MH  - *MAP Kinase Kinase Kinase 1
MH  - *MAP Kinase Kinase Kinases
MH  - Mice
MH  - Mitogen-Activated Protein Kinase 1
MH  - *Mitogen-Activated Protein Kinases
MH  - Molecular Sequence Data
MH  - Protein-Serine-Threonine Kinases/*metabolism
MH  - Recombinant Proteins/genetics/metabolism
MH  - Signal Transduction
MH  - Transfection
MH  - Yeasts/genetics
EDAT- 1999/09/03 00:00
MHDA- 1999/09/03 00:01
CRDT- 1999/09/03 00:00
PHST- 1999/09/03 00:00 [pubmed]
PHST- 1999/09/03 00:01 [medline]
PHST- 1999/09/03 00:00 [entrez]
AID - S0014579399010844 [pii]
AID - 10.1016/s0014-5793(99)01084-4 [doi]
PST - ppublish
SO  - FEBS Lett. 1999 Sep 3;457(3):385-8. doi: 10.1016/s0014-5793(99)01084-4.