PMID- 10471807
OWN - NLM
STAT- MEDLINE
DCOM- 19991012
LR  - 20190621
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 457
IP  - 3
DP  - 1999 Sep 3
TI  - Human membrane type-4 matrix metalloproteinase (MT4-MMP) is encoded by a novel
      major transcript: isolation of complementary DNA clones for human and mouse
      mt4-mmp transcripts.
PG  - 353-6
AB  - Five distinct membrane-type matrix metalloproteinases (MT-MMP) have been reported
      by cDNA cloning. However, the mt4-mmp gene product (MMP-17) has not been
      identified yet in spite of the cDNA isolation [Puente et al. (1996), Cancer Res. 
      56, 944-949]. In this study, we re-examined the transcripts for human mt4-mmp by 
      5' RACE and identified two types of transcripts. The minor one corresponded to
      the cDNA reported by Puente et al. and failed to express protein, and the other
      is the major transcript that has an extended open reading frame and expressed 67 
      and 71 kDa translation products. Thus, functional mt4-mmp has been identified for
      the first time.
FAU - Kajita, M
AU  - Kajita M
AD  - Department of Cancer Cell Research, Institute of Medical Science, The University 
      of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo, Japan.
FAU - Kinoh, H
AU  - Kinoh H
FAU - Ito, N
AU  - Ito N
FAU - Takamura, A
AU  - Takamura A
FAU - Itoh, Y
AU  - Itoh Y
FAU - Okada, A
AU  - Okada A
FAU - Sato, H
AU  - Sato H
FAU - Seiki, M
AU  - Seiki M
LA  - eng
SI  - GENBANK/AB021224
SI  - GENBANK/AB021225
SI  - GENBANK/AB021226
SI  - GENBANK/AB021227
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (DNA Primers)
RN  - 0 (DNA, Complementary)
RN  - EC 3.4.24.- (MMP17 protein, human)
RN  - EC 3.4.24.- (Matrix Metalloproteinases)
RN  - EC 3.4.24.- (Matrix Metalloproteinases, Membrane-Associated)
RN  - EC 3.4.24.- (Metalloendopeptidases)
RN  - EC 3.4.24.- (Mmp17 protein, mouse)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Blotting, Western
MH  - Breast Neoplasms/enzymology/genetics
MH  - COS Cells
MH  - Carcinoma/enzymology/genetics
MH  - DNA Primers
MH  - DNA, Complementary/*isolation & purification
MH  - Humans
MH  - *Matrix Metalloproteinases
MH  - Matrix Metalloproteinases, Membrane-Associated
MH  - Metalloendopeptidases/*genetics/immunology/metabolism
MH  - Mice
MH  - Molecular Sequence Data
MH  - Nucleic Acid Amplification Techniques
MH  - Protein Biosynthesis
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Transcription, Genetic
MH  - Tumor Cells, Cultured
EDAT- 1999/09/03 00:00
MHDA- 1999/09/03 00:01
CRDT- 1999/09/03 00:00
PHST- 1999/09/03 00:00 [pubmed]
PHST- 1999/09/03 00:01 [medline]
PHST- 1999/09/03 00:00 [entrez]
AID - S0014-5793(99)01065-0 [pii]
AID - 10.1016/s0014-5793(99)01065-0 [doi]
PST - ppublish
SO  - FEBS Lett. 1999 Sep 3;457(3):353-6. doi: 10.1016/s0014-5793(99)01065-0.