PMID- 10471199
OWN - NLM
STAT- MEDLINE
DCOM- 19991019
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 271
IP  - 1
DP  - 1999 Aug 13
TI  - Circadian rhythms and light responsiveness of mammalian clock gene, Clock and
      BMAL1, transcripts in the rat retina.
PG  - 1-4
AB  - Circadian expression and light-responsiveness of the mammalian clock genes, Clock
      and BMAL1, in the rat retina were examined by in situ hydbribization under
      constant darkness. A small but significant daily variation was detected in the
      Clock transcript level, but not in BMAL1. Light increased the Clock and BMAL1
      expressions significantly when examined 60 min after exposure. The light-induced 
      gene expression was phase-dependent for Clock and peaked at ZT2, while rather
      constant throughout the day for BMAL1. These findings suggest that Clock and
      BMAL1 play different roles in the generation of circadian rhytm in the retina
      from those in the suprachiasmatic nucleus. Different roles are also suggested
      between the two genes in the photic signal transduction in the retina.
FAU - Namihira, M
AU  - Namihira M
AD  - Department of Physiology, Hokkaido University School of Medicine, Sapporo, Japan.
FAU - Honma, S
AU  - Honma S
FAU - Abe, H
AU  - Abe H
FAU - Tanahashi, Y
AU  - Tanahashi Y
FAU - Ikeda, M
AU  - Ikeda M
FAU - Honma, K
AU  - Honma K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (ARNTL Transcription Factors)
RN  - 0 (Basic Helix-Loop-Helix Transcription Factors)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
RN  - EC 2.3.1.48 (CLOCK Proteins)
RN  - EC 2.3.1.48 (Clock protein, rat)
SB  - IM
MH  - ARNTL Transcription Factors
MH  - Animals
MH  - Basic Helix-Loop-Helix Transcription Factors
MH  - CLOCK Proteins
MH  - Circadian Rhythm/*genetics
MH  - Darkness
MH  - *Gene Expression Regulation
MH  - Helix-Loop-Helix Motifs
MH  - Light
MH  - Male
MH  - Rats
MH  - Rats, Wistar
MH  - Retina/*physiology
MH  - Trans-Activators/*genetics
MH  - Transcription Factors/*genetics
MH  - *Transcription, Genetic
EDAT- 1999/09/02 00:00
MHDA- 1999/09/02 00:01
CRDT- 1999/09/02 00:00
PHST- 1999/09/02 00:00 [pubmed]
PHST- 1999/09/02 00:01 [medline]
PHST- 1999/09/02 00:00 [entrez]
AID - S0304394099004073 [pii]
AID - 10.1016/s0304-3940(99)00407-3 [doi]
PST - ppublish
SO  - Neurosci Lett. 1999 Aug 13;271(1):1-4. doi: 10.1016/s0304-3940(99)00407-3.