PMID- 10471116
OWN - NLM
STAT- MEDLINE
DCOM- 20000124
LR  - 20190915
IS  - 0952-3278 (Print)
IS  - 0952-3278 (Linking)
VI  - 60
IP  - 5-6
DP  - 1999 May-Jun
TI  - Human very long-chain acyl-CoA synthetase and two human homologs: initial
      characterization and relationship to fatty acid transport protein.
PG  - 323-8
AB  - Several human genes with a high degree of homology to rat very long-chain
      acyl-CoA synthetase (rVLCS) and mouse fatty acid transport protein (mFATP) were
      identified. Full-length cDNA clones were obtained for three genes, and predicted 
      amino acid sequences were generated. Initial characterization indicated that one 
      gene was most likely hVLCS, the human ortholog of rVLCS. The other two (hVLCS-H1 
      and hVLCS-H2) were more closely related to rVLCS than to mFATP. Phylogenetic
      analysis of amino acid sequences confirmed that hVLCS-H1 and hVLCS-H2 were
      evolutionarily closer to VLCSs than FATPs. Alignment of predicted amino acid
      sequences of human, rat and mouse VLCSs and FATPs revealed the existence of two
      highly conserved motifs. While one motif is also present in long-chain acyl-CoA
      synthetases, the other serves to distinguish the VLCS/FATP family from the
      long-chain synthetase family. Elucidation of the biochemical functions of all
      VLCS/FATP family members should provide new insights into cellular fatty acid
      metabolism.
FAU - Watkins, P A
AU  - Watkins PA
AD  - Kennedy Krieger Institute, Baltimore, MD 21205, USA. watkins@kennedykrieger.org
FAU - Pevsner, J
AU  - Pevsner J
FAU - Steinberg, S J
AU  - Steinberg SJ
LA  - eng
GR  - HD10981/HD/NICHD NIH HHS/United States
GR  - HD24061/HD/NICHD NIH HHS/United States
GR  - NS10533/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Scotland
TA  - Prostaglandins Leukot Essent Fatty Acids
JT  - Prostaglandins, leukotrienes, and essential fatty acids
JID - 8802730
RN  - 0 (Carrier Proteins)
RN  - 0 (Fatty Acid Transport Proteins)
RN  - 0 (Fatty Acids)
RN  - 0 (Isoenzymes)
RN  - 0 (Membrane Proteins)
RN  - 0 (Membrane Transport Proteins)
RN  - 0 (Repressor Proteins)
RN  - 0 (Saccharomyces cerevisiae Proteins)
RN  - EC 6.2.1.- (Coenzyme A Ligases)
RN  - EC 6.2.1.3 (FAA2 protein, S cerevisiae)
RN  - EC 6.2.1.3 (long-chain-fatty-acid-CoA ligase)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Carrier Proteins/*chemistry
MH  - Cloning, Molecular
MH  - Coenzyme A Ligases/*chemistry/metabolism
MH  - Conserved Sequence
MH  - Fatty Acid Transport Proteins
MH  - Fatty Acids/metabolism
MH  - Humans
MH  - Isoenzymes/chemistry/metabolism
MH  - Membrane Proteins/*chemistry
MH  - *Membrane Transport Proteins
MH  - Molecular Sequence Data
MH  - *Repressor Proteins
MH  - *Saccharomyces cerevisiae Proteins
MH  - *Sequence Homology, Amino Acid
MH  - Substrate Specificity
EDAT- 1999/09/02 00:00
MHDA- 1999/09/02 00:01
CRDT- 1999/09/02 00:00
PHST- 1999/09/02 00:00 [pubmed]
PHST- 1999/09/02 00:01 [medline]
PHST- 1999/09/02 00:00 [entrez]
AID - 10.1016/s0952-3278(99)80007-6 [doi]
PST - ppublish
SO  - Prostaglandins Leukot Essent Fatty Acids. 1999 May-Jun;60(5-6):323-8. doi:
      10.1016/s0952-3278(99)80007-6.