PMID- 10470087
OWN - NLM
STAT- MEDLINE
DCOM- 19990924
LR  - 20131121
IS  - 1078-8956 (Print)
IS  - 1078-8956 (Linking)
VI  - 5
IP  - 9
DP  - 1999 Sep
TI  - Obesity in the mouse model of pro-opiomelanocortin deficiency responds to
      peripheral melanocortin.
PG  - 1066-70
AB  - Pro-opiomelanocortin (POMC)-derived peptides (the melanocortins
      adrenocorticotropin, alpha-, beta- and gamma-melanocyte stimulating hormone; and 
      the endogenous opioid beta-endorphin) have a diverse array of biological
      activities, including roles in pigmentation, adrenocortical function and
      regulation of energy stores, and in the immune system and the central and
      peripheral nervous systems. We show here that mice lacking the POMC-derived
      peptides have obesity, defective adrenal development and altered pigmentation.
      This phenotype is similar to that of the recently identified human POMC-deficient
      patients. When treated with a stable alpha-melanocyte-stimulating hormone
      agonist, mutant mice lost more than 40% of their excess weight after 2 weeks. Our
      results identify the POMC-null mutant mouse as a model for studying the human
      POMC-null syndrome, and indicate the therapeutic use of peripheral melanocortin
      in the treatment of obesity.
FAU - Yaswen, L
AU  - Yaswen L
AD  - Unit on Molecular Genetics, Clinical Neuroscience Branch, NIMH, 49 Convent Drive,
      Bethesda, Maryland 20892,USA.
FAU - Diehl, N
AU  - Diehl N
FAU - Brennan, M B
AU  - Brennan MB
FAU - Hochgeschwender, U
AU  - Hochgeschwender U
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Nat Med
JT  - Nature medicine
JID - 9502015
RN  - 0 (Catecholamines)
RN  - 0 (Leptin)
RN  - 0 (Proteins)
RN  - 4964P6T9RB (Aldosterone)
RN  - 581-05-5 (alpha-MSH)
RN  - 66796-54-1 (Pro-Opiomelanocortin)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - W980KJ009P (Corticosterone)
SB  - IM
CIN - Nat Med. 1999 Sep;5(9):984-5. PMID: 10470066
MH  - Adrenal Glands/drug effects/pathology/physiopathology
MH  - Adrenocorticotropic Hormone/deficiency/genetics/metabolism
MH  - Aldosterone/blood
MH  - Animals
MH  - Catecholamines/blood
MH  - Corticosterone/blood
MH  - *Disease Models, Animal
MH  - Female
MH  - Gene Deletion
MH  - Hair Color
MH  - Humans
MH  - Leptin
MH  - Mice
MH  - Obesity/blood/drug therapy/*physiopathology
MH  - Phenotype
MH  - Pro-Opiomelanocortin/*deficiency/genetics/metabolism
MH  - Proteins/analysis
MH  - Weight Loss/drug effects
MH  - alpha-MSH/agonists/analogs & derivatives/*pharmacology/therapeutic use
EDAT- 1999/09/02 09:00
MHDA- 2001/03/23 10:01
CRDT- 1999/09/02 09:00
PHST- 1999/09/02 09:00 [pubmed]
PHST- 2001/03/23 10:01 [medline]
PHST- 1999/09/02 09:00 [entrez]
AID - 10.1038/12506 [doi]
PST - ppublish
SO  - Nat Med. 1999 Sep;5(9):1066-70. doi: 10.1038/12506.