PMID- 10470034
OWN - NLM
STAT- MEDLINE
DCOM- 19991013
LR  - 20190910
IS  - 0968-0004 (Print)
IS  - 0968-0004 (Linking)
VI  - 24
IP  - 9
DP  - 1999 Sep
TI  - p21-activated protein kinase: a crucial component of morphological signaling?
PG  - 350-5
AB  - The mechanisms by which Rho family GTPases (Rho, Rac and Cdc42) regulate
      coordinated changes to the actin cytoskeleton are being elucidated. This review
      will focus on the current evidence that the p21-activated kinases (PAKs) are
      involved in regulating some of the diverse cytoskeletal changes induced by Rac
      and Cdc42. PAKs have been shown to be required for processes including neurite
      formation and axonal guidance, development of cell polarity and motile responses.
      Signaling molecules interacting with PAKs that might contribute to the regulation
      of such processes have recently been identified.
FAU - Daniels, R H
AU  - Daniels RH
AD  - Depts of Immunology and Cell Biology, The Scripps Research Institute, 10550 N.
      Torrey Pines Road, La Jolla, CA 92037, USA.
FAU - Bokoch, G M
AU  - Bokoch GM
LA  - eng
GR  - AR45738/AR/NIAMS NIH HHS/United States
GR  - GM39434/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - England
TA  - Trends Biochem Sci
JT  - Trends in biochemical sciences
JID - 7610674
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (Guanine Nucleotide Exchange Factors)
RN  - 0 (Rho Guanine Nucleotide Exchange Factors)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.11.1 (Lim Kinases)
RN  - EC 2.7.11.1 (Protein-Serine-Threonine Kinases)
RN  - EC 2.7.11.1 (p21-Activated Kinases)
RN  - EC 3.6.1.- (GTP-Binding Proteins)
RN  - EC 3.6.4.1 (Myosins)
RN  - EC 3.6.5.2 (cdc42 GTP-Binding Protein)
RN  - EC 3.6.5.2 (rho GTP-Binding Proteins)
SB  - IM
MH  - Animals
MH  - Cell Cycle Proteins/*metabolism
MH  - Cell Polarity
MH  - Cytoskeleton/*metabolism
MH  - Enzyme Activation
MH  - GTP-Binding Proteins/*metabolism
MH  - *Guanine Nucleotide Exchange Factors
MH  - Lim Kinases
MH  - Myosins/metabolism
MH  - Protein Kinases/metabolism
MH  - Protein-Serine-Threonine Kinases/chemistry/*metabolism
MH  - Rho Guanine Nucleotide Exchange Factors
MH  - Signal Transduction/*physiology
MH  - cdc42 GTP-Binding Protein
MH  - p21-Activated Kinases
MH  - rho GTP-Binding Proteins
RF  - 50
EDAT- 1999/09/02 00:00
MHDA- 1999/09/02 00:01
CRDT- 1999/09/02 00:00
PHST- 1999/09/02 00:00 [pubmed]
PHST- 1999/09/02 00:01 [medline]
PHST- 1999/09/02 00:00 [entrez]
AID - S0968-0004(99)01442-5 [pii]
AID - 10.1016/s0968-0004(99)01442-5 [doi]
PST - ppublish
SO  - Trends Biochem Sci. 1999 Sep;24(9):350-5. doi: 10.1016/s0968-0004(99)01442-5.