PMID- 10469660
OWN - NLM
STAT- MEDLINE
DCOM- 19991028
LR  - 20131121
IS  - 0261-4189 (Print)
IS  - 0261-4189 (Linking)
VI  - 18
IP  - 17
DP  - 1999 Sep 1
TI  - Mammalian TAF(II)30 is required for cell cycle progression and specific cellular 
      differentiation programmes.
PG  - 4823-34
AB  - The two alleles of the 30 kDa TATA-binding protein associated factor (TAF(II)30) 
      gene, have been targeted by homologous recombination in murine F9 embryonal
      carcinoma cells and subsequently disrupted using a Cre recombinase-loxP strategy.
      The TAF(II)30-null cells are not viable, but are rescued by the expression of
      human TAF(II)30. Cells lacking TAF(II)30 are blocked in G(1)/G(0) phase of the
      cell cycle and undergo apoptosis. In agreement with the G(1) arrest phenotype,
      the expression of cyclin E is impaired and the retinoblastoma protein is
      hypophosphorylated in the TAF(II)30-null cells. Interestingly, retinoic acid (RA)
      treatment prevented TAF(II)30-null cell death and induced primitive endodermal
      differentiation. In contrast, the RA- and cAMP-induced parietal endodermal
      differentiation was impaired in the TAF(II)30-null cells. Thus, TAF(II)30 is not 
      indispensable for class II gene transcription in general, but seems to be
      required for the expression of a subset of genes.
FAU - Metzger, D
AU  - Metzger D
AD  - Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS/INSERM/ULP, 
      College de France, BP 163-67404 Illkirch Cedex, CU de Strasbourg, France.
FAU - Scheer, E
AU  - Scheer E
FAU - Soldatov, A
AU  - Soldatov A
FAU - Tora, L
AU  - Tora L
LA  - eng
SI  - GENBANK/AJ249987
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - EMBO J
JT  - The EMBO journal
JID - 8208664
RN  - 0 (Antineoplastic Agents)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (TAF10 protein, human)
RN  - 0 (TATA-Binding Protein Associated Factors)
RN  - 0 (Transcription Factor TFIID)
RN  - 0 (Transcription Factors)
RN  - 0 (Viral Proteins)
RN  - 5688UTC01R (Tretinoin)
RN  - EC 2.7.7.- (Cre recombinase)
RN  - EC 2.7.7.- (Integrases)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/pharmacology
MH  - Apoptosis
MH  - Carcinoma, Embryonal/genetics
MH  - Cell Cycle/*physiology
MH  - Cell Differentiation/*physiology
MH  - Cell Division/physiology
MH  - DNA-Binding Proteins/*physiology
MH  - Gene Expression Regulation, Developmental
MH  - Gene Expression Regulation, Neoplastic
MH  - Integrases/metabolism
MH  - Mice
MH  - Mice, Knockout
MH  - Models, Genetic
MH  - Mutagenesis, Insertional
MH  - Stem Cells/cytology
MH  - *TATA-Binding Protein Associated Factors
MH  - Time Factors
MH  - *Transcription Factor TFIID
MH  - Transcription Factors/*physiology
MH  - Tretinoin/pharmacology
MH  - Tumor Cells, Cultured
MH  - *Viral Proteins
PMC - PMC1171554
EDAT- 1999/09/02 00:00
MHDA- 1999/09/02 00:01
CRDT- 1999/09/02 00:00
PHST- 1999/09/02 00:00 [pubmed]
PHST- 1999/09/02 00:01 [medline]
PHST- 1999/09/02 00:00 [entrez]
AID - 10.1093/emboj/18.17.4823 [doi]
PST - ppublish
SO  - EMBO J. 1999 Sep 1;18(17):4823-34. doi: 10.1093/emboj/18.17.4823.