PMID- 10469646
OWN - NLM
STAT- MEDLINE
DCOM- 19991028
LR  - 20211203
IS  - 0261-4189 (Print)
IS  - 0261-4189 (Linking)
VI  - 18
IP  - 17
DP  - 1999 Sep 1
TI  - The Drosophila STE20-like kinase misshapen is required downstream of the Frizzled
      receptor in planar polarity signaling.
PG  - 4669-78
AB  - The Drosophila misshapen (msn) gene is a member of the STE20 kinase family. We
      show that msn acts in the Frizzled (Fz) mediated epithelial planar polarity (EPP)
      signaling pathway in eyes and wings. Both msn loss- and gain-of-function result
      in defective ommatidial polarity and wing hair formation. Genetic and biochemical
      analyses indicate that msn acts downstream of fz and dishevelled (dsh) in the
      planar polarity pathway, and thus implicates an STE20-like kinase in
      Fz/Dsh-mediated signaling. This demonstrates that seven-pass transmembrane
      receptors can signal via members of the STE20 kinase family in higher eukaryotes.
      We also show that Msn acts in EPP signaling through the JNK (Jun-N-terminal
      kinase) module as it does in dorsal closure. Although at the level of Fz/Dsh
      there is no apparent redundancy in this pathway, the downstream effector JNK/MAPK
      (mitogen-activated protein kinase) module is redundant in planar polarity
      generation. To address the nature of this redundancy, we provide evidence for an 
      involvement of the related MAP kinases of the p38 subfamily in planar polarity
      signaling downstream of Msn.
FAU - Paricio, N
AU  - Paricio N
AD  - Developmental Biology Programme, EMBL, Meyerhofstrasse 1, 69117 Heidelberg,
      Germany.
FAU - Feiguin, F
AU  - Feiguin F
FAU - Boutros, M
AU  - Boutros M
FAU - Eaton, S
AU  - Eaton S
FAU - Mlodzik, M
AU  - Mlodzik M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - EMBO J
JT  - The EMBO journal
JID - 8208664
RN  - 0 (Actins)
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Dishevelled Proteins)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Frizzled Receptors)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Phosphoproteins)
RN  - 0 (Receptors, G-Protein-Coupled)
RN  - 0 (Saccharomyces cerevisiae Proteins)
RN  - 0 (dsh protein, Drosophila)
RN  - 0 (fz protein, Drosophila)
RN  - EC 2.7.1.- (msn protein, Drosophila)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.1 (hpo protein, Drosophila)
RN  - EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
RN  - EC 2.7.11.25 (MAP Kinase Kinase Kinases)
RN  - EC 2.7.11.25 (STE20 protein, S cerevisiae)
SB  - IM
MH  - Actins/metabolism
MH  - Adaptor Proteins, Signal Transducing
MH  - Alleles
MH  - Animals
MH  - *Cell Polarity
MH  - Dishevelled Proteins
MH  - Drosophila/*enzymology
MH  - *Drosophila Proteins
MH  - Frizzled Receptors
MH  - Intracellular Signaling Peptides and Proteins
MH  - JNK Mitogen-Activated Protein Kinases
MH  - MAP Kinase Kinase Kinases
MH  - Membrane Proteins/genetics/*physiology
MH  - Mitogen-Activated Protein Kinases/genetics/metabolism
MH  - Models, Genetic
MH  - Mutagenesis
MH  - Phenotype
MH  - Phosphoproteins/genetics/metabolism
MH  - Phosphorylation
MH  - Photoreceptor Cells, Invertebrate/physiology
MH  - Protein Serine-Threonine Kinases/genetics/metabolism/*physiology
MH  - Receptors, G-Protein-Coupled
MH  - *Saccharomyces cerevisiae Proteins
MH  - Signal Transduction
MH  - Wings, Animal/metabolism
PMC - PMC1171540
EDAT- 1999/09/02 00:00
MHDA- 1999/09/02 00:01
CRDT- 1999/09/02 00:00
PHST- 1999/09/02 00:00 [pubmed]
PHST- 1999/09/02 00:01 [medline]
PHST- 1999/09/02 00:00 [entrez]
AID - 10.1093/emboj/18.17.4669 [doi]
PST - ppublish
SO  - EMBO J. 1999 Sep 1;18(17):4669-78. doi: 10.1093/emboj/18.17.4669.