PMID- 10469456
OWN - NLM
STAT- MEDLINE
DCOM- 20000107
LR  - 20061115
IS  - 1045-2257 (Print)
IS  - 1045-2257 (Linking)
VI  - 26
IP  - 2
DP  - 1999 Oct
TI  - Homozygous deletion at the 9q32-33 candidate tumor suppressor locus in primary
      human bladder cancer.
PG  - 171-5
AB  - Loss of heterozygosity (LOH) on chromosome arm 9q is the most frequent genetic
      alteration found in superficial and invasive transitional cell carcinoma (TCC) in
      a previous microsatellite-based deletion mapping study of the bladder and upper
      urinary tract, indicating the presence of one or more important tumor suppressor 
      genes (TSGs). One of the putative tumor suppressor loci on 9q (DBC1) was mapped
      to 9q32-33 and the candidate region was localized within a single YAC. We report 
      here a case of superficial papillary TCC, which showed a homozygous deletion
      encompassing this candidate tumor suppressor region. The region of homozygous
      deletion spanned the interval between D9S275 and AFMA239XA9 at 9q32-33, and was
      estimated to be </=6 cM. Although homozygous deletion mapping did not narrow down
      the candidate tumor suppressor region, this case provides further support for the
      presence of a TSG for TCC in this chromosomal region. To our knowledge, this is
      the first report to show homozygous deletion at 9q32-33 in TCC or any other type 
      of human tumor. Genes Chromosomes Cancer 26:171-175, 1999.
CI  - Copyright 1999 Wiley-Liss, Inc.
FAU - Nishiyama, H
AU  - Nishiyama H
AD  - ICRF Cancer Medicine Research Unit, St. James's University Hospital, Leeds, U.K.
FAU - Takahashi, T
AU  - Takahashi T
FAU - Kakehi, Y
AU  - Kakehi Y
FAU - Habuchi, T
AU  - Habuchi T
FAU - Knowles, M A
AU  - Knowles MA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genes Chromosomes Cancer
JT  - Genes, chromosomes & cancer
JID - 9007329
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Carcinoma, Transitional Cell/*genetics
MH  - *Chromosome Deletion
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 9/*genetics
MH  - Genes, Tumor Suppressor/*genetics
MH  - Genetic Markers
MH  - *Homozygote
MH  - Humans
MH  - Loss of Heterozygosity/*genetics
MH  - Urinary Bladder Neoplasms/*genetics
EDAT- 1999/09/01 00:00
MHDA- 1999/09/01 00:01
CRDT- 1999/09/01 00:00
PHST- 1999/09/01 00:00 [pubmed]
PHST- 1999/09/01 00:01 [medline]
PHST- 1999/09/01 00:00 [entrez]
AID - 10.1002/(SICI)1098-2264(199910)26:2<171::AID-GCC10>3.0.CO;2-B [pii]
PST - ppublish
SO  - Genes Chromosomes Cancer. 1999 Oct;26(2):171-5.