PMID- 10469308
OWN - NLM
STAT- MEDLINE
DCOM- 19990930
LR  - 20071114
IS  - 0022-202X (Print)
IS  - 0022-202X (Linking)
VI  - 113
IP  - 2
DP  - 1999 Aug
TI  - Genetic mapping and physical cloning of UVB susceptibility region in mice.
PG  - 224-9
AB  - One of the most important goals of cancer research is to identify environmental
      and host factors that contribute to the malignant state. Human skin cancers are
      among the few tumor types for which the predominant environmental carcinogen is
      known. Ultraviolet light, a component of sunlight, is an important cause of skin 
      cancer in humans. In humans and mice, ultraviolet B radiation induces systematic 
      and local immunosuppression. A consequence of that is inappropriate immune
      surveillance of somatic tissues for evidence of malignantly transformed cells.
      The impairment of contact hypersensitivity, as it develops early and correlates
      well with tumor frequency in various mouse strains, has been used for over 15 y
      as a model of immunologic events occurring in photocarcinogenesis. In mice, as
      well as in humans, ultraviolet B radiation induced impairment of contact
      hypersensitivity is not uniform in all individuals; some individuals are
      susceptible to the deleterious effects of ultraviolet B, whereas others are
      resistant to ultraviolet B. We have defined the genetic locus responsible for
      ultraviolet B susceptibility and resistance in mice within the Bat5 and H-2D
      segment of the mouse chromosome 17.
FAU - Handel-Fernandez, M E
AU  - Handel-Fernandez ME
AD  - Department of Microbiology and Immunology, University of Miami School of
      Medicine, FL 33101, USA.
FAU - Kurimoto, I
AU  - Kurimoto I
FAU - Streilein, J W
AU  - Streilein JW
FAU - Vincek, V
AU  - Vincek V
LA  - eng
GR  - AR 44130/AR/NIAMS NIH HHS/United States
GR  - CA75757/CA/NCI NIH HHS/United States
GR  - R01 CA64083/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Invest Dermatol
JT  - The Journal of investigative dermatology
JID - 0426720
SB  - IM
MH  - Animals
MH  - Cell Line
MH  - Chromosome Mapping
MH  - Cloning, Molecular
MH  - Genetic Predisposition to Disease/*genetics
MH  - Humans
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C3H
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred DBA
MH  - Skin Neoplasms/*genetics
MH  - *Ultraviolet Rays
EDAT- 1999/09/01 00:00
MHDA- 1999/09/01 00:01
CRDT- 1999/09/01 00:00
PHST- 1999/09/01 00:00 [pubmed]
PHST- 1999/09/01 00:01 [medline]
PHST- 1999/09/01 00:00 [entrez]
AID - S0022-202X(15)40566-4 [pii]
AID - 10.1046/j.1523-1747.1999.00683.x [doi]
PST - ppublish
SO  - J Invest Dermatol. 1999 Aug;113(2):224-9. doi: 10.1046/j.1523-1747.1999.00683.x.