PMID- 10468588
OWN - NLM
STAT- MEDLINE
DCOM- 19991007
LR  - 20210109
IS  - 0027-8424 (Print)
IS  - 0027-8424 (Linking)
VI  - 96
IP  - 18
DP  - 1999 Aug 31
TI  - Transcription repression by Xenopus ET and its human ortholog TBX3, a gene
      involved in ulnar-mammary syndrome.
PG  - 10212-7
AB  - T box (Tbx) genes are a family of developmental regulators with more than 20
      members recently identified in invertebrates and vertebrates. Mutations in Tbx
      genes have been found to cause several human diseases. Our understanding of
      functional mechanisms of Tbx products has come mainly from the prototypical
      T/Brachyury, which is a transcription activator. We previously discovered ET, a
      Tbx gene expressed in Xenopus embryos. We report here that ET is an ortholog of
      the human Tbx3 and that ET is a repressor of basal and activated transcription.
      Functional dissection of the ET protein reveals a novel transcription-repression 
      domain highly conserved among ET, human TBX3, and TBX2. These results reveal a
      new transcription repressor domain, show the existence of a subfamily of
      transcription repressors in the Tbx superfamily, and provide a basis for
      understanding etiology of diseases caused by Tbx3 mutations.
FAU - He, M l
AU  - He Ml
AD  - Department of Anatomy and Neurobiology, Washington University School of Medicine,
      St. Louis, MO 63110, USA.
FAU - Wen, L
AU  - Wen L
FAU - Campbell, C E
AU  - Campbell CE
FAU - Wu, J Y
AU  - Wu JY
FAU - Rao, Y
AU  - Rao Y
LA  - eng
SI  - GENBANK/AF170708
SI  - GENBANK/AF173940
GR  - R01 EY014576-03/EY/NEI NIH HHS/United States
GR  - DK48796/DK/NIDDK NIH HHS/United States
GR  - R01 GM070967-02/GM/NIGMS NIH HHS/United States
GR  - R01 DK048796/DK/NIDDK NIH HHS/United States
GR  - R01 CA114197-01A2/CA/NCI NIH HHS/United States
GR  - R01 EY014576/EY/NEI NIH HHS/United States
GR  - R01 GM070967/GM/NIGMS NIH HHS/United States
GR  - R01 CA114197/CA/NCI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Recombinant Fusion Proteins)
RN  - 0 (Repressor Proteins)
RN  - 0 (T-Box Domain Proteins)
RN  - 0 (TBX3 protein, human)
RN  - 0 (Tbx3 protein, Xenopus)
RN  - 0 (Transcription Factors)
RN  - 0 (Xenopus Proteins)
RN  - 0 (transcription repression factor ET, Xenopus)
SB  - IM
EIN - Proc Natl Acad Sci U S A 1999 Nov 9;96(23):13589
MH  - Amino Acid Sequence
MH  - Animals
MH  - Breast/*abnormalities
MH  - Cell Line
MH  - Congenital Abnormalities/*genetics
MH  - Embryo, Nonmammalian/metabolism
MH  - Gene Expression Regulation, Developmental
MH  - Humans
MH  - Molecular Sequence Data
MH  - Recombinant Fusion Proteins/biosynthesis
MH  - Repressor Proteins/chemistry/*genetics
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
MH  - Syndrome
MH  - *T-Box Domain Proteins
MH  - Transcription Factors/chemistry/*genetics
MH  - *Transcription, Genetic
MH  - Ulna/*abnormalities
MH  - *Xenopus Proteins
MH  - Xenopus laevis/embryology/genetics
PMC - PMC17868
EDAT- 1999/09/01 09:00
MHDA- 2000/03/04 09:00
CRDT- 1999/09/01 09:00
PHST- 1999/09/01 09:00 [pubmed]
PHST- 2000/03/04 09:00 [medline]
PHST- 1999/09/01 09:00 [entrez]
AID - 10.1073/pnas.96.18.10212 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10212-7. doi:
      10.1073/pnas.96.18.10212.