PMID- 10465784
OWN - NLM
STAT- MEDLINE
DCOM- 19991007
LR  - 20190516
IS  - 0890-9369 (Print)
IS  - 0890-9369 (Linking)
VI  - 13
IP  - 16
DP  - 1999 Aug 15
TI  - ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal
      transduction pathway.
PG  - 2059-71
AB  - Activation of NF-kappaB as a consequence of signaling through the Toll and IL-1
      receptors is a major element of innate immune responses. We report the
      identification and characterization of a novel intermediate in these signaling
      pathways that bridges TRAF6 to MEKK-1. This adapter protein, which we have named 
      ECSIT (evolutionarily conserved signaling intermediate in Toll pathways), is
      specific for the Toll/IL-1 pathways and is a regulator of MEKK-1 processing.
      Expression of wild-type ECSIT accelerates processing of MEKK-1, whereas a
      dominant-negative fragment of ECSIT blocks MEKK-1 processing and activation of
      NF-kappaB. These results indicate an important role for ECSIT in signaling to
      NF-kappaB and suggest that processing of MEKK-1 is required for its function in
      the Toll/IL-1 pathway.
FAU - Kopp, E
AU  - Kopp E
AD  - Section of Immunobiology and Department of Molecular Biophysics and Biochemistry,
      Howard Hughes Medical Institute (HHMI), Yale University School of Medicine, New
      Haven, Connecticut 06520 USA.
FAU - Medzhitov, R
AU  - Medzhitov R
FAU - Carothers, J
AU  - Carothers J
FAU - Xiao, C
AU  - Xiao C
FAU - Douglas, I
AU  - Douglas I
FAU - Janeway, C A
AU  - Janeway CA
FAU - Ghosh, S
AU  - Ghosh S
LA  - eng
SI  - GENBANK/AF182510
SI  - GENBANK/AF182511
GR  - R01-AI4334/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genes Dev
JT  - Genes & development
JID - 8711660
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Drosophila Proteins)
RN  - 0 (ECSIT protein, Drosophila)
RN  - 0 (Insect Proteins)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (NF-kappa B)
RN  - 0 (Proteins)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Receptors, Interleukin-1)
RN  - 0 (TNF Receptor-Associated Factor 6)
RN  - 0 (Tl protein, Drosophila)
RN  - 0 (Toll-Like Receptors)
RN  - EC 2.7.11.1 (Protein-Serine-Threonine Kinases)
RN  - EC 2.7.11.25 (MAP Kinase Kinase Kinase 1)
RN  - EC 2.7.11.25 (MAP3K1 protein, human)
RN  - EC 2.7.11.25 (Map3k1 protein, mouse)
SB  - IM
SB  - S
MH  - Adaptor Proteins, Signal Transducing
MH  - Amino Acid Sequence
MH  - Animals
MH  - Biological Evolution
MH  - Cell Line, Transformed
MH  - Cloning, Molecular
MH  - Drosophila
MH  - *Drosophila Proteins
MH  - Enzyme Activation
MH  - Humans
MH  - Insect Proteins/*metabolism
MH  - *MAP Kinase Kinase Kinase 1
MH  - Membrane Glycoproteins/*metabolism
MH  - Mice
MH  - Molecular Sequence Data
MH  - NF-kappa B/metabolism
MH  - Protein Processing, Post-Translational
MH  - Protein-Serine-Threonine Kinases/metabolism
MH  - Proteins/genetics/*metabolism
MH  - Receptors, Cell Surface/*metabolism
MH  - *Receptors, Immunologic
MH  - Receptors, Interleukin-1/*metabolism
MH  - Saccharomyces cerevisiae
MH  - *Signal Transduction
MH  - TNF Receptor-Associated Factor 6
MH  - Toll-Like Receptors
PMC - PMC316957
EDAT- 1999/08/31 00:00
MHDA- 1999/08/31 00:01
CRDT- 1999/08/31 00:00
PHST- 1999/08/31 00:00 [pubmed]
PHST- 1999/08/31 00:01 [medline]
PHST- 1999/08/31 00:00 [entrez]
AID - 10.1101/gad.13.16.2059 [doi]
PST - ppublish
SO  - Genes Dev. 1999 Aug 15;13(16):2059-71. doi: 10.1101/gad.13.16.2059.