PMID- 10464095
OWN - NLM
STAT- MEDLINE
DCOM- 19990914
LR  - 20190619
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 285
IP  - 5432
DP  - 1999 Aug 27
TI  - Gene expression profile of aging and its retardation by caloric restriction.
PG  - 1390-3
AB  - The gene expression profile of the aging process was analyzed in skeletal muscle 
      of mice. Use of high-density oligonucleotide arrays representing 6347 genes
      revealed that aging resulted in a differential gene expression pattern indicative
      of a marked stress response and lower expression of metabolic and biosynthetic
      genes. Most alterations were either completely or partially prevented by caloric 
      restriction, the only intervention known to retard aging in mammals.
      Transcriptional patterns of calorie-restricted animals suggest that caloric
      restriction retards the aging process by causing a metabolic shift toward
      increased protein turnover and decreased macromolecular damage.
FAU - Lee, C K
AU  - Lee CK
AD  - Environmental Toxicology Center, Institute on Aging, Department of Genetics,
      University of Wisconsin, Madison, WI 53706, USA.
FAU - Klopp, R G
AU  - Klopp RG
FAU - Weindruch, R
AU  - Weindruch R
FAU - Prolla, T A
AU  - Prolla TA
LA  - eng
GR  - P01 AG11915/AG/NIA NIH HHS/United States
GR  - R01 CA78723/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Proteins)
RN  - 0 (RNA, Messenger)
SB  - IM
CIN - Science. 1999 Nov 26;286(5445):1679-80. PMID: 10610562
MH  - Aging/*genetics
MH  - Animals
MH  - DNA Damage/genetics
MH  - DNA Repair/genetics
MH  - *Diet
MH  - *Energy Intake
MH  - Energy Metabolism/genetics
MH  - *Gene Expression Regulation
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mitochondria, Muscle/metabolism
MH  - Muscle, Skeletal/innervation/*metabolism
MH  - Oligonucleotide Array Sequence Analysis
MH  - Oxidative Stress/genetics
MH  - Proteins/metabolism
MH  - RNA, Messenger/genetics/metabolism
EDAT- 1999/08/28 09:00
MHDA- 2000/02/19 09:00
CRDT- 1999/08/28 09:00
PHST- 1999/08/28 09:00 [pubmed]
PHST- 2000/02/19 09:00 [medline]
PHST- 1999/08/28 09:00 [entrez]
AID - 7785 [pii]
AID - 10.1126/science.285.5432.1390 [doi]
PST - ppublish
SO  - Science. 1999 Aug 27;285(5432):1390-3. doi: 10.1126/science.285.5432.1390.