PMID- 10463614
OWN - NLM
STAT- MEDLINE
DCOM- 19990916
LR  - 20061115
IS  - 0008-5472 (Print)
IS  - 0008-5472 (Linking)
VI  - 59
IP  - 16
DP  - 1999 Aug 15
TI  - A new MAGE gene with ubiquitous expression does not code for known MAGE antigens 
      recognized by T cells.
PG  - 4100-3
AB  - A number of genes of the MAGE family have been shown to code for antigens that
      are recognized on many human tumors by autologous CTLs. These antigens should be 
      strictly tumor specific because the encoding MAGE genes are not expressed in
      normal adult cells, except for male germ-line cells, which lack HLA expression.
      Here, we report that a distant relative of the previously identified MAGE genes
      is expressed in many, if not all, normal tissues. This gene, which was named
      MAGE-D, is located in Xp11. Its exon-intron structure is completely different
      from that of the other MAGE genes. None of the 20 MAGE antigenic peptides
      presently known to be recognized by T lymphocytes is encoded by the new MAGE
      gene. It appears, therefore, that this new finding leaves intact the tumor
      specificity of the antigens encoded by the MAGE genes that are expressed only in 
      tumor and germ-line cells.
FAU - Lucas, S
AU  - Lucas S
AD  - Ludwig Institute for Cancer Research, and Cellular Genetics Unit, Universite
      Catholique de Louvain, Brussels, Belgium. lucas@licr.ucl.ac.be
FAU - Brasseur, F
AU  - Brasseur F
FAU - Boon, T
AU  - Boon T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (MAGED1 protein, human)
RN  - 0 (Neoplasm Proteins)
SB  - IM
MH  - Adult
MH  - Amino Acid Sequence
MH  - Antigen Presentation
MH  - Antigens, Neoplasm/*genetics/immunology
MH  - Chromosome Mapping
MH  - Cytotoxicity, Immunologic/genetics
MH  - Gene Expression
MH  - Humans
MH  - Male
MH  - Molecular Sequence Data
MH  - Neoplasm Proteins/*genetics/immunology
MH  - Sequence Alignment
MH  - T-Lymphocytes/*immunology
MH  - *X Chromosome
EDAT- 1999/08/27 00:00
MHDA- 1999/08/27 00:01
CRDT- 1999/08/27 00:00
PHST- 1999/08/27 00:00 [pubmed]
PHST- 1999/08/27 00:01 [medline]
PHST- 1999/08/27 00:00 [entrez]
PST - ppublish
SO  - Cancer Res. 1999 Aug 15;59(16):4100-3.