PMID- 10463355
OWN - NLM
STAT- MEDLINE
DCOM- 19991026
LR  - 20190831
IS  - 0340-5354 (Print)
IS  - 0340-5354 (Linking)
VI  - 246
IP  - 7
DP  - 1999 Jul
TI  - Varying occurrence of vocal cord paralysis in a family with autosomal dominant
      hereditary motor and sensory neuropathy.
PG  - 552-5
AB  - A white British family with the axonal form of hereditary motor and sensory
      neuropathy (HMSN, type II) contained one member who developed a recurrent
      laryngeal nerve palsy at the age of 41 years, in addition to 4 years of
      symptomatic polyneuropathy and an abducens nerve palsy. Neither of the other
      family members (the mother and sister) with electrophysiologically confirmed
      polyneuropathy had any neuropathic symptoms in the limbs or laryngeal or
      respiratory muscle involvement. An autosomal dominant pattern of inheritance is
      likely. This is a second report of this rare form of HMSN (type IIC) in which
      there is associated laryngeal or respiratory muscle weakness. This family differs
      from the two previously reported pedigrees in which laryngeal or diaphragm
      weakness had commenced within the first two decades. The discovery of
      asymptomatic family members attests to the diagnostic value of clinical and
      electrophysiological study of first-degree relatives when laryngeal or bulbar
      symptoms develop in the context of chronic axonal polyneuropathy. HMSN type IIC
      should be distinguished from the more common forms of HMSN - type IIA, in which
      axonal polyneuropathy is restricted to the limbs, and type IIB, which is of early
      onset and associated with foot ulceration.
FAU - Donaghy, M
AU  - Donaghy M
AD  - University Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK.
FAU - Kennett, R
AU  - Kennett R
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - J Neurol
JT  - Journal of neurology
JID - 0423161
SB  - IM
MH  - Adult
MH  - Aged
MH  - Diagnosis, Differential
MH  - Electromyography
MH  - Female
MH  - Hereditary Sensory and Motor Neuropathy/*complications/genetics/physiopathology
MH  - Humans
MH  - Laryngeal Nerves/*pathology
MH  - Male
MH  - Middle Aged
MH  - Muscle Weakness/etiology/physiopathology
MH  - Pedigree
MH  - Vocal Cord Paralysis/etiology/*physiopathology
EDAT- 1999/08/27 00:00
MHDA- 1999/08/27 00:01
CRDT- 1999/08/27 00:00
PHST- 1999/08/27 00:00 [pubmed]
PHST- 1999/08/27 00:01 [medline]
PHST- 1999/08/27 00:00 [entrez]
AID - 10.1007/s004150050402 [doi]
PST - ppublish
SO  - J Neurol. 1999 Jul;246(7):552-5. doi: 10.1007/s004150050402.