PMID- 10462052
OWN - NLM
STAT- MEDLINE
DCOM- 19990907
LR  - 20190621
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 456
IP  - 3
DP  - 1999 Aug 13
TI  - Cloning, tissue distribution, subcellular localization and overexpression of
      murine histidine-rich Ca2+ binding protein.
PG  - 399-402
AB  - The histidine-rich Ca2+ binding protein (HRC) resides in the sarcoplasmic
      reticulum of muscle and binds Ca2+. Since Ca2+ concentrations can regulate gene
      expression via calcineurin, the mouse homologue of HRC (mHRC) was isolated and
      characterized. mHRC was detected in muscle progenitor cells, in primary clonal
      thymic tumors and a tumor cell line, suggesting a broader role for mHRC than in
      Ca2+ storage during muscle contraction. mHRC was present in the perinuclear
      region of myoblasts. To examine if it can regulate gene expression, mHRC was
      overexpressed in cells differentiating into cardiac and skeletal muscle. mHRC had
      no effect on cardiogenesis or myogenesis. Therefore, if mHRC plays a role in the 
      regulation of gene expression during cellular differentiation, it does not appear
      to be either rate-limiting or inhibitory.
FAU - Ridgeway, A G
AU  - Ridgeway AG
AD  - Department of Biochemistry, University of Western Ontario, London, Canada.
FAU - Petropoulos, H
AU  - Petropoulos H
FAU - Siu, A
AU  - Siu A
FAU - Ball, J K
AU  - Ball JK
FAU - Skerjanc, I S
AU  - Skerjanc IS
LA  - eng
SI  - GENBANK/AF158597
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Calcium-Binding Proteins)
RN  - 0 (Hrc protein, mouse)
RN  - 139135-52-7 (HRC protein, human)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Calcium-Binding Proteins/*genetics/*metabolism
MH  - Cell Differentiation/physiology
MH  - Cell Line
MH  - Cloning, Molecular
MH  - Gene Expression Regulation
MH  - Humans
MH  - Mice
MH  - Molecular Sequence Data
MH  - Muscle Development
MH  - Muscle, Skeletal/growth & development/metabolism
MH  - Repetitive Sequences, Amino Acid
MH  - Sequence Homology, Amino Acid
MH  - Subcellular Fractions
MH  - Thymus Neoplasms/metabolism
MH  - Tumor Cells, Cultured
EDAT- 1999/08/26 00:00
MHDA- 1999/08/26 00:01
CRDT- 1999/08/26 00:00
PHST- 1999/08/26 00:00 [pubmed]
PHST- 1999/08/26 00:01 [medline]
PHST- 1999/08/26 00:00 [entrez]
AID - S0014-5793(99)00993-X [pii]
AID - 10.1016/s0014-5793(99)00993-x [doi]
PST - ppublish
SO  - FEBS Lett. 1999 Aug 13;456(3):399-402. doi: 10.1016/s0014-5793(99)00993-x.