PMID- 10462049
OWN - NLM
STAT- MEDLINE
DCOM- 19990907
LR  - 20190621
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 456
IP  - 3
DP  - 1999 Aug 13
TI  - ADP-ribosylation factor (ARF)-like 4, 6, and 7 represent a subgroup of the ARF
      family characterization by rapid nucleotide exchange and a nuclear localization
      signal.
PG  - 384-8
AB  - The novel ARF-like GTPase ARL7 is a close relative of ARL4 and ARL6 (71% and 59%)
      identical amino acids). A striking characteristic of these GTPases is their basic
      C-terminus which, when fused to the C-terminus of green fluorescent protein
      (GFP), targets the constructs to the nucleus of transfected COS-7 cells. Full
      length ARL4 was detected in both nuclear and extranuclear compartments, whereas a
      construct of ARL4 lacking its C-terminus was excluded from the nucleus.
      Nucleotide exchange rates of recombinant ARL4, ARL6 and ARL7 were similar and
      appeared considerably higher than those of other members of the ARF family (ARF1,
      ARP). It is concluded that ARL4, ARL6 and ARL7 form a subgroup within the ARF
      family with similar, possibly nuclear, function.
FAU - Jacobs, S
AU  - Jacobs S
AD  - Institut fur Pharmakologie und Toxikologie, Medizinische Fakultat der RWTH
      Aachen, Germany.
FAU - Schilf, C
AU  - Schilf C
FAU - Fliegert, F
AU  - Fliegert F
FAU - Koling, S
AU  - Koling S
FAU - Weber, Y
AU  - Weber Y
FAU - Schurmann, A
AU  - Schurmann A
FAU - Joost, H G
AU  - Joost HG
LA  - eng
SI  - GENBANK/Y17804
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Luminescent Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Recombinant Proteins)
RN  - 147336-22-9 (Green Fluorescent Proteins)
RN  - 5Z93L87A1R (Guanine)
RN  - EC 3.6.1.- (GTP Phosphohydrolases)
RN  - EC 3.6.1.- (GTP-Binding Proteins)
RN  - EC 3.6.5.2 (ADP-Ribosylation Factor 1)
RN  - EC 3.6.5.2 (ADP-Ribosylation Factors)
RN  - EC 3.6.5.2 (ARL4A protein, human)
SB  - IM
MH  - ADP-Ribosylation Factor 1
MH  - ADP-Ribosylation Factors
MH  - Amino Acid Sequence
MH  - Animals
MH  - COS Cells/metabolism
MH  - Cell Nucleus/*metabolism
MH  - Cloning, Molecular
MH  - Esophagus/chemistry
MH  - Female
MH  - GTP Phosphohydrolases/genetics/*metabolism
MH  - GTP-Binding Proteins/*genetics/*metabolism
MH  - Green Fluorescent Proteins
MH  - Guanine/*metabolism
MH  - Humans
MH  - Kidney/chemistry
MH  - Luminescent Proteins/genetics/metabolism
MH  - Male
MH  - Molecular Sequence Data
MH  - RNA, Messenger/analysis
MH  - Recombinant Proteins/genetics/metabolism
MH  - Sequence Analysis
MH  - Sequence Homology, Amino Acid
MH  - Subcellular Fractions
MH  - Testis/chemistry
MH  - Transfection
MH  - Uterus/chemistry
EDAT- 1999/08/26 00:00
MHDA- 1999/08/26 00:01
CRDT- 1999/08/26 00:00
PHST- 1999/08/26 00:00 [pubmed]
PHST- 1999/08/26 00:01 [medline]
PHST- 1999/08/26 00:00 [entrez]
AID - S0014579399007590 [pii]
AID - 10.1016/s0014-5793(99)00759-0 [doi]
PST - ppublish
SO  - FEBS Lett. 1999 Aug 13;456(3):384-8. doi: 10.1016/s0014-5793(99)00759-0.