PMID- 10461880
OWN - NLM
STAT- MEDLINE
DCOM- 19990914
LR  - 20190630
IS  - 0022-3042 (Print)
IS  - 0022-3042 (Linking)
VI  - 73
IP  - 3
DP  - 1999 Sep
TI  - Extensive alternative splicing in the 5'-untranslated region of the rat and human
      neuropeptide Y Y5 receptor genes regulates receptor expression.
PG  - 913-20
AB  - Neuropeptide Y (NPY) elicits a plethora of physiological effects by interacting
      with several distinct G protein-coupled receptors. Activation of one of these
      receptors, the NPY Y5 receptor, is thought to result in increased food intake,
      anticonvulsant effects, attenuation of opiate withdrawal, inhibition of neuronal 
      activity, and alteration of renal function. Several alternatively spliced human
      and rat NPY Y5 receptor cDNAs have been isolated that use different combinations 
      of exons in the 5'-untranslated region. The various human NPY Y5 receptor cDNAs
      appear to be differentially expressed in different brain regions. The level of
      human NPY Y5 receptor expressed transiently in COS1 cells was significantly
      influenced by the sequence of the 5'-untranslated region. These results indicate 
      that alternative splicing in the 5'-untranslated region of the human and rat NPY 
      Y5 receptor genes occurs in a tissue-specific manner and is one mechanism by
      which cells control the level of NPY Y5 receptor expression.
FAU - Parker, E M
AU  - Parker EM
AD  - Department of CNS and Cardiovascular Research, Schering-Plough Research
      Institute, Kenilworth, New Jersey 07033, USA.
FAU - Xia, L
AU  - Xia L
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Neurochem
JT  - Journal of neurochemistry
JID - 2985190R
RN  - 0 (5' Untranslated Regions)
RN  - 0 (DNA, Complementary)
RN  - 0 (Receptors, Neuropeptide Y)
RN  - 0 (neuropeptide Y5 receptor)
SB  - IM
MH  - 5' Untranslated Regions/*genetics
MH  - *Alternative Splicing
MH  - Animals
MH  - Base Sequence
MH  - Brain/metabolism
MH  - COS Cells
MH  - DNA, Complementary/metabolism
MH  - *Gene Expression Regulation
MH  - Humans
MH  - Molecular Sequence Data
MH  - Mutagenesis, Site-Directed
MH  - Radioligand Assay
MH  - Rats
MH  - Receptors, Neuropeptide Y/biosynthesis/*genetics
MH  - Reverse Transcriptase Polymerase Chain Reaction
EDAT- 1999/08/26 00:00
MHDA- 1999/08/26 00:01
CRDT- 1999/08/26 00:00
PHST- 1999/08/26 00:00 [pubmed]
PHST- 1999/08/26 00:01 [medline]
PHST- 1999/08/26 00:00 [entrez]
AID - 10.1046/j.1471-4159.1999.0730913.x [doi]
PST - ppublish
SO  - J Neurochem. 1999 Sep;73(3):913-20. doi: 10.1046/j.1471-4159.1999.0730913.x.