PMID- 10461186
OWN - NLM
STAT- MEDLINE
DCOM- 19991020
LR  - 20191024
IS  - 0962-8924 (Print)
IS  - 0962-8924 (Linking)
VI  - 9
IP  - 9
DP  - 1999 Sep
TI  - Gamma-tubulin complexes: size does matter.
PG  - 339-42
AB  - gamma-Tubulin is a conserved component of all microtubule-organizing centres and 
      is required for these organelles to nucleate microtubule polymerization. However,
      the mechanism of nucleation is not known. In addition to its localization to
      organizing centres, a large pool of gamma-tubulin exists in the cytoplasm in a
      complex with other proteins. The size of the gamma-tubulin complex and number of 
      associated proteins vary among organisms, and the functional significance of
      these differences is unknown. Recently, the nature of these gamma-tubulin
      complexes has been explored in different organisms, and this has led us closer to
      a molecular understanding of microtubule nucleation.
FAU - Jeng, R
AU  - Jeng R
AD  - Dept of Biological Sciences, Stanford University, Stanford, CA 94305-5020, USA.
FAU - Stearns, T
AU  - Stearns T
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Review
PL  - England
TA  - Trends Cell Biol
JT  - Trends in cell biology
JID - 9200566
RN  - 0 (Fungal Proteins)
RN  - 0 (Insect Proteins)
RN  - 0 (Macromolecular Substances)
RN  - 0 (Tubulin)
SB  - IM
MH  - Animal Population Groups/metabolism
MH  - Animals
MH  - Centrosome/chemistry/ultrastructure
MH  - Drosophila melanogaster/metabolism
MH  - Fungal Proteins/chemistry
MH  - Fungi/metabolism
MH  - Insect Proteins/chemistry
MH  - Macromolecular Substances
MH  - Microtubules/chemistry/ultrastructure
MH  - Morphogenesis
MH  - Spindle Apparatus/chemistry/ultrastructure
MH  - Structure-Activity Relationship
MH  - Tubulin/*chemistry
RF  - 36
EDAT- 1999/08/26 00:00
MHDA- 1999/08/26 00:01
CRDT- 1999/08/26 00:00
PHST- 1999/08/26 00:00 [pubmed]
PHST- 1999/08/26 00:01 [medline]
PHST- 1999/08/26 00:00 [entrez]
AID - S0962-8924(99)01621-9 [pii]
AID - 10.1016/s0962-8924(99)01621-9 [doi]
PST - ppublish
SO  - Trends Cell Biol. 1999 Sep;9(9):339-42. doi: 10.1016/s0962-8924(99)01621-9.