PMID- 10460003
OWN - NLM
STAT- MEDLINE
DCOM- 19990924
LR  - 20190921
IS  - 0169-5002 (Print)
IS  - 0169-5002 (Linking)
VI  - 24
IP  - 3
DP  - 1999 Jun
TI  - Cadherin and catenin expression in normal human bronchial epithelium and
      non-small cell lung cancer.
PG  - 157-68
AB  - Cadherins are transmembrane cell adhesion molecules (CAMS) that mediate cell-cell
      interactions and are important for maintenance of epithelial cell integrity. This
      function is dependent on an indirect interaction between the cytoplasmic domain
      of the cadherin molecule with three cytoplasmic proteins known as alpha-, beta-, 
      and gamma-catenin (-cat). Growing evidence suggests that alterations in cadherin 
      or catenin expression or function may be important to the development of an
      invasive or metastatic phenotype. Immunohistochemical techniques were used to
      study the expression of the two major epithelial cadherins, E-cadherin (E-cad)
      and P-cadherin (P-cad) as well as alpha- and gamma-cat in normal bronchial
      epithelium and in a series of carefully TMN-staged pulmonary adenocarcinomas (n =
      21) and squamous cell carcinomas (n = 7). The cadherin profile of normal
      pseudostratified bronchial epithelium was heterogeneous. Basilar cells strongly
      expressed P-cad, alpha- and gamma-cat, while columnar cells moderately expressed 
      E-cad, alpha- and gamma-cat. In contrast to other epithelial tumors, E-cad on
      non-small cell lung carcinomas was actually upregulated, however, a decrease in
      P-cad expression was noted in 68%. At least one cadherin or catenin was
      downregulated, compared to normal bronchial epithelium, in 82% of tumors
      examined. With the exception of an association between loss of P-cad expression
      and poorly differentiated state, changes in cadherin and catenin expression
      levels were not significantly correlated to tumor stage, cell type, or nodal
      status. These findings illustrate that alteration of expression of cadherins and 
      catenins are often found in non-small cell lung carcinoma when compared to the
      progenitor bronchial epithelium, and may play a role in the development of the
      malignant phenotype.
FAU - Smythe, W R
AU  - Smythe WR
AD  - M.D. Anderson Cancer Center, Department of Thoracic and Cardiovascular Surgery,
      The University of Texas, Houston 77030, USA. rsmythenotes.mdacc.tmc.edu.
FAU - Williams, J P
AU  - Williams JP
FAU - Wheelock, M J
AU  - Wheelock MJ
FAU - Johnson, K R
AU  - Johnson KR
FAU - Kaiser, L R
AU  - Kaiser LR
FAU - Albelda, S M
AU  - Albelda SM
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Lung Cancer
JT  - Lung cancer (Amsterdam, Netherlands)
JID - 8800805
RN  - 0 (CTNNA1 protein, human)
RN  - 0 (Cadherins)
RN  - 0 (Cytoskeletal Proteins)
RN  - 0 (Desmoplakins)
RN  - 0 (JUP protein, human)
RN  - 0 (alpha Catenin)
RN  - 0 (gamma Catenin)
SB  - IM
MH  - Bronchi/cytology/*metabolism
MH  - Cadherins/*metabolism
MH  - Carcinoma, Non-Small-Cell Lung/*metabolism/pathology
MH  - Cytoskeletal Proteins/metabolism
MH  - Desmoplakins
MH  - Epithelium/metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Lung Neoplasms/*metabolism/pathology
MH  - Neoplasm Metastasis
MH  - Statistics, Nonparametric
MH  - alpha Catenin
MH  - gamma Catenin
EDAT- 1999/08/25 00:00
MHDA- 1999/08/25 00:01
CRDT- 1999/08/25 00:00
PHST- 1999/08/25 00:00 [pubmed]
PHST- 1999/08/25 00:01 [medline]
PHST- 1999/08/25 00:00 [entrez]
AID - S0169-5002(99)00032-X [pii]
AID - 10.1016/s0169-5002(99)00032-x [doi]
PST - ppublish
SO  - Lung Cancer. 1999 Jun;24(3):157-68. doi: 10.1016/s0169-5002(99)00032-x.