PMID- 10459014
OWN - NLM
STAT- MEDLINE
DCOM- 19990923
LR  - 20211203
IS  - 0021-9525 (Print)
IS  - 0021-9525 (Linking)
VI  - 146
IP  - 4
DP  - 1999 Aug 23
TI  - Regulation of APC activity by phosphorylation and regulatory factors.
PG  - 791-800
AB  - Ubiquitin-dependent proteolysis of Cut2/Pds1 and Cyclin B is required for sister 
      chromatid separation and exit from mitosis, respectively. Anaphase-promoting
      complex/cyclosome (APC) specifically ubiquitinates Cut2/Pds1 at
      metaphase-anaphase transition, and ubiquitinates Cyclin B in late mitosis and G1 
      phase. However, the exact regulatory mechanism of substrate-specific activation
      of mammalian APC with the right timing remains to be elucidated. We found that
      not only the binding of the activators Cdc20 and Cdh1 and the inhibitor Mad2 to
      APC, but also the phosphorylation of Cdc20 and Cdh1 by Cdc2-Cyclin B and that of 
      APC by Polo-like kinase and cAMP-dependent protein kinase, regulate APC activity.
      The cooperation of the phosphorylation/dephosphorylation and the regulatory
      factors in regulation of APC activity may thus control the precise progression of
      mitosis.
FAU - Kotani, S
AU  - Kotani S
AD  - Tsukuba Life Science Center, The Institute of Physical and Chemical Research,
      Tsukuba, Ibaraki 305-0074, Japan.
FAU - Tanaka, H
AU  - Tanaka H
FAU - Yasuda, H
AU  - Yasuda H
FAU - Todokoro, K
AU  - Todokoro K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Retracted Publication
PL  - United States
TA  - J Cell Biol
JT  - The Journal of cell biology
JID - 0375356
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Antigens, CD)
RN  - 0 (CDC20 protein, S cerevisiae)
RN  - 0 (CDH1 protein, S cerevisiae)
RN  - 0 (CDH1 protein, human)
RN  - 0 (CKS1 protein, S cerevisiae)
RN  - 0 (Cadherins)
RN  - 0 (Calcium-Binding Proteins)
RN  - 0 (Carrier Proteins)
RN  - 0 (Cdc20 Proteins)
RN  - 0 (Cdh1 Proteins)
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (Cut2 protein, S pombe)
RN  - 0 (Cyclin B)
RN  - 0 (Fungal Proteins)
RN  - 0 (MAD2 protein, S cerevisiae)
RN  - 0 (Mad2 Proteins)
RN  - 0 (Mad2l1 protein, mouse)
RN  - 0 (Mad2l2 protein, mouse)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Recombinant Fusion Proteins)
RN  - 0 (Saccharomyces cerevisiae Proteins)
RN  - 0 (Schizosaccharomyces pombe Proteins)
RN  - 0 (Securin)
RN  - 0 (Suc1 protein, S pombe)
RN  - 0 (Ubiquitins)
RN  - 0 (mad2 protein, S pombe)
RN  - EC 2.3.2.23 (Ubiquitin-Protein Ligase Complexes)
RN  - EC 2.3.2.27 (Anaphase-Promoting Complex-Cyclosome)
RN  - EC 2.3.2.27 (Ubiquitin-Protein Ligases)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.1 (polo-like kinase 1)
RN  - EC 2.7.11.11 (Cyclic AMP-Dependent Protein Kinases)
RN  - EC 2.7.11.22 (CDC2 Protein Kinase)
RN  - EC 2.7.11.22 (Maturation-Promoting Factor)
RN  - EC 6.- (Ligases)
SB  - IM
RIN - Tanaka H, Yasuda H, Todokoro K. J Cell Biol. 2005 Apr 11;169(1):205. PMID:
      15824138
MH  - 3T3 Cells
MH  - Adaptor Proteins, Signal Transducing
MH  - Anaphase-Promoting Complex-Cyclosome
MH  - Animals
MH  - Antigens, CD
MH  - CDC2 Protein Kinase/metabolism
MH  - Cadherins
MH  - Calcium-Binding Proteins/*metabolism
MH  - *Carrier Proteins
MH  - Cdc20 Proteins
MH  - Cdh1 Proteins
MH  - Cell Cycle Proteins/*metabolism
MH  - Cyclic AMP-Dependent Protein Kinases/metabolism
MH  - Cyclin B/metabolism
MH  - Enzyme Activation/drug effects
MH  - Fungal Proteins/*metabolism
MH  - Humans
MH  - Ligases/*metabolism
MH  - Mad2 Proteins
MH  - Maturation-Promoting Factor/metabolism
MH  - Mice
MH  - Mitosis
MH  - Nuclear Proteins
MH  - Phosphorylation/drug effects
MH  - Protein Kinases/metabolism
MH  - Protein Serine-Threonine Kinases
MH  - Proto-Oncogene Proteins
MH  - Recombinant Fusion Proteins/metabolism
MH  - *Saccharomyces cerevisiae Proteins
MH  - *Schizosaccharomyces pombe Proteins
MH  - Securin
MH  - *Ubiquitin-Protein Ligase Complexes
MH  - Ubiquitin-Protein Ligases
MH  - Ubiquitins/metabolism
PMC - PMC2156135
EDAT- 1999/08/25 00:00
MHDA- 1999/08/25 00:01
CRDT- 1999/08/25 00:00
PHST- 1999/08/25 00:00 [pubmed]
PHST- 1999/08/25 00:01 [medline]
PHST- 1999/08/25 00:00 [entrez]
AID - 10.1083/jcb.146.4.791 [doi]
PST - ppublish
SO  - J Cell Biol. 1999 Aug 23;146(4):791-800. doi: 10.1083/jcb.146.4.791.