PMID- 10459009
OWN - NLM
STAT- MEDLINE
DCOM- 19990923
LR  - 20191023
IS  - 0021-9525 (Print)
IS  - 0021-9525 (Linking)
VI  - 146
IP  - 4
DP  - 1999 Aug 23
TI  - The developmental role of warthog, the notch modifier encoding Drab6.
PG  - 731-40
AB  - The warthog (wrt) gene, recovered as a modifier for Notch signaling, was found to
      encode the Drosophila homologue of rab6, Drab6. Vertebrate and yeast homologues
      of this protein have been shown to regulate Golgi network to TGN trafficking. To 
      study the function of this protein in the development of a multicellular
      organism, we analyzed three different warthog mutants. The first was an R62C
      point mutation, the second a genomic null, and the third was an engineered
      GTP-bound form. Our studies show, contrary to yeast, that the Drosophila
      homologue of rab6 is an essential gene. However, it has limited effects on
      development beyond the larval stage. Only the mechanosensory bristles on the
      head, notum, and scutellum are affected by warthog mutations. We present models
      for the modifying effect of Drab6 on Notch signaling.
FAU - Purcell, K
AU  - Purcell K
AD  - Department of Cell Biology, Yale University, New Haven, Connecticut 06510, USA.
FAU - Artavanis-Tsakonas, S
AU  - Artavanis-Tsakonas S
LA  - eng
SI  - GENBANK/AF163011
SI  - GENBANK/AF163015
GR  - NS26084/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Cell Biol
JT  - The Journal of cell biology
JID - 0375356
RN  - 0 (Carrier Proteins)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Insect Proteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (N protein, Drosophila)
RN  - 0 (Rab6 protein)
RN  - 0 (Receptors, Notch)
RN  - 86-01-1 (Guanosine Triphosphate)
RN  - EC 3.6.5.2 (rab GTP-Binding Proteins)
RN  - EC 3.6.5.2 (ras Proteins)
SB  - IM
SB  - S
MH  - Alleles
MH  - Amino Acid Sequence
MH  - Animals
MH  - Carrier Proteins/chemistry/*genetics/*metabolism
MH  - Cloning, Molecular
MH  - Drosophila Proteins
MH  - Drosophila melanogaster/anatomy & histology/embryology/genetics/*growth &
      development
MH  - Gene Expression
MH  - Genes, Essential/genetics
MH  - Genes, Insect/genetics
MH  - Genetic Complementation Test
MH  - Guanosine Triphosphate/metabolism
MH  - Insect Proteins/chemistry/genetics/metabolism
MH  - Larva/genetics/growth & development
MH  - Membrane Proteins/*metabolism
MH  - Molecular Sequence Data
MH  - Mosaicism
MH  - Mutation
MH  - Phenotype
MH  - Receptors, Notch
MH  - Sequence Homology, Amino Acid
MH  - Signal Transduction
MH  - *rab GTP-Binding Proteins
MH  - ras Proteins/chemistry/*genetics/*metabolism
PMC - PMC2156142
EDAT- 1999/08/25 00:00
MHDA- 1999/08/25 00:01
CRDT- 1999/08/25 00:00
PHST- 1999/08/25 00:00 [pubmed]
PHST- 1999/08/25 00:01 [medline]
PHST- 1999/08/25 00:00 [entrez]
AID - 10.1083/jcb.146.4.731 [doi]
PST - ppublish
SO  - J Cell Biol. 1999 Aug 23;146(4):731-40. doi: 10.1083/jcb.146.4.731.