PMID- 10458910
OWN - NLM
STAT- MEDLINE
DCOM- 19990930
LR  - 20111117
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 60
IP  - 1
DP  - 1999 Aug 15
TI  - Identification of INSL5, a new member of the insulin superfamily.
PG  - 50-6
AB  - A new member of the insulin gene superfamily (INSL5) was identified by searching 
      EST databases for the presence of the conserved insulin B-chain cysteine motif.
      Human and murine INSL5 are both polypeptides of 135 amino acids, matching the
      classical signature of the insulin superfamily. Through the B- and A-chain
      regions, human INSL5 has 48% identity to shark relaxin, 40% identity to human
      relaxin, and 34% identity to human Leydig insulin-like factor. Northern blot
      analysis detected expression of human INSL5 in rectal, colon, and uterine tissue 
      and of murine INSL5 only in thymic tissue. Using quantitative RT-PCR, expression 
      of murine INSL5 was detected in the highest quantity in colon followed by thymus,
      and minimal expression was seen in testis. By radiation hybrid mapping and the
      use of surrounding markers, human INSL5 maps to chromosome 1 in the 1p31.1 to
      1p22.3 region.
CI  - Copyright 1999 Academic Press.
FAU - Conklin, D
AU  - Conklin D
AD  - ZymoGenetics, Inc., 1201 Eastlake Avenue East, Seattle, Washington, 98102, USA.
FAU - Lofton-Day, C E
AU  - Lofton-Day CE
FAU - Haldeman, B A
AU  - Haldeman BA
FAU - Ching, A
AU  - Ching A
FAU - Whitmore, T E
AU  - Whitmore TE
FAU - Lok, S
AU  - Lok S
FAU - Jaspers, S
AU  - Jaspers S
LA  - eng
SI  - GENBANK/AF133816
SI  - GENBANK/AF133817
PT  - Journal Article
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (DNA, Complementary)
RN  - 0 (Hormones)
RN  - 0 (Insl5 protein, mouse)
RN  - 0 (Insulin)
RN  - 0 (Peptide Hormones)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Blotting, Northern
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 1/genetics
MH  - Contig Mapping
MH  - DNA, Complementary/chemistry/genetics
MH  - Female
MH  - Gene Expression
MH  - Hormones/*genetics
MH  - Humans
MH  - Hybrid Cells
MH  - Insulin/*genetics
MH  - Male
MH  - Mice
MH  - Molecular Sequence Data
MH  - Peptide Hormones
MH  - RNA, Messenger/genetics/metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Sequence Analysis, DNA
MH  - Sequence Homology, Amino Acid
MH  - Tissue Distribution
EDAT- 1999/08/25 00:00
MHDA- 1999/08/25 00:01
CRDT- 1999/08/25 00:00
PHST- 1999/08/25 00:00 [pubmed]
PHST- 1999/08/25 00:01 [medline]
PHST- 1999/08/25 00:00 [entrez]
AID - 10.1006/geno.1999.5899 [doi]
AID - S0888-7543(99)95899-8 [pii]
PST - ppublish
SO  - Genomics. 1999 Aug 15;60(1):50-6. doi: 10.1006/geno.1999.5899.