PMID- 10458909
OWN - NLM
STAT- MEDLINE
DCOM- 19990930
LR  - 20071114
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 60
IP  - 1
DP  - 1999 Aug 15
TI  - Novel human and mouse annexin A10 are linked to the genome duplications during
      early chordate evolution.
PG  - 40-9
AB  - We have identified and characterized a 12th subfamily of vertebrate annexins by
      systematic analysis of the primary structure, chromosomal mapping, and molecular 
      evolution of unique cDNA and protein sequences from human and mouse. Distinctive 
      features included rare expression, a codon deletion in conserved repeat 3, and an
      unusual ablation of the type II calcium-binding sites in tetrad core repeats 1,
      3, and 4. The paralogy of novel annexin A10 (following revised nomenclature) was 
      confirmed by FISH-mapping human ANXA10 to chromosome 4q33 and genetic linkage
      mapping mouse Anxa10 to midchromosome 8. Phylogenetic analysis established that
      the 5' and 3' halves of the annexin A6 octad are more closely related to annexins
      A5 and A10, respectively, than they are to each other. Molecular date estimates, 
      paralogy linkage maps between human chromosomes 4 and 5, and annexin structural
      considerations led to the proposal that annexins A5 and A10 may have been the
      direct progenitors of annexin A6 octad formation via chromosomal duplication
      during the genome expansion in early chordates.
CI  - Copyright 1999 Academic Press.
FAU - Morgan, R O
AU  - Morgan RO
AD  - Faculty of Medicine, University of Oviedo, Oviedo, E-33006, Spain.
      mpff@dwarf1.quimica.uniovi.es
FAU - Jenkins, N A
AU  - Jenkins NA
FAU - Gilbert, D J
AU  - Gilbert DJ
FAU - Copeland, N G
AU  - Copeland NG
FAU - Balsara, B R
AU  - Balsara BR
FAU - Testa, J R
AU  - Testa JR
FAU - Fernandez, M P
AU  - Fernandez MP
LA  - eng
SI  - GENBANK/AJ238978
SI  - GENBANK/AJ238979
GR  - CA-06927/CA/NCI NIH HHS/United States
GR  - PM95-0152/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (ANXA10 protein, human)
RN  - 0 (Annexins)
RN  - 0 (Anxa10 protein, mouse)
RN  - 0 (DNA, Complementary)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Annexins/*genetics
MH  - Base Sequence
MH  - Chordata, Nonvertebrate/*genetics
MH  - Chromosome Mapping
MH  - Chromosomes/genetics
MH  - Chromosomes, Human, Pair 4/genetics
MH  - Crosses, Genetic
MH  - DNA, Complementary/chemistry/genetics
MH  - *Evolution, Molecular
MH  - Female
MH  - *Gene Duplication
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Molecular Sequence Data
MH  - Muridae
MH  - Phylogeny
MH  - Sequence Alignment
MH  - Sequence Analysis, DNA
MH  - Sequence Homology, Amino Acid
MH  - Sequence Homology, Nucleic Acid
EDAT- 1999/08/25 00:00
MHDA- 1999/08/25 00:01
CRDT- 1999/08/25 00:00
PHST- 1999/08/25 00:00 [pubmed]
PHST- 1999/08/25 00:01 [medline]
PHST- 1999/08/25 00:00 [entrez]
AID - 10.1006/geno.1999.5895 [doi]
AID - S0888-7543(99)95895-0 [pii]
PST - ppublish
SO  - Genomics. 1999 Aug 15;60(1):40-9. doi: 10.1006/geno.1999.5895.