PMID- 10456327
OWN - NLM
STAT- MEDLINE
DCOM- 19990830
LR  - 20190621
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 456
IP  - 2
DP  - 1999 Aug 6
TI  - The autocrine motility factor receptor gene encodes a novel type of seven
      transmembrane protein.
PG  - 295-300
AB  - Autocrine motility factor receptor (AMFR) is a cell surface glycoprotein of
      molecular weight 78,000 (gp78), mediating cell motility signaling in vitro and
      metastasis in vivo. Here, we cloned the full-length cDNAs for both human and
      mouse AMFR genes. Both genes encode a protein of 643 amino acids containing a
      seven transmembrane domain, a RING-H2 motif and a leucine zipper motif and showed
      a 94.7% amino acid sequence identity to each other. Analysis of the amino acid
      sequence of AMFR with protein databases revealed no significant homology with all
      known seven transmembrane proteins, but a significant structural similarity to a 
      hypothetical protein of Caenorhabditis elegans, F26E4.11. Thus, AMFR is a highly 
      conserved gene which encodes a novel type of seven transmembrane protein.
FAU - Shimizu, K
AU  - Shimizu K
AD  - Biology Division, National Cancer Center Research Institute, Tokyo, Japan.
FAU - Tani, M
AU  - Tani M
FAU - Watanabe, H
AU  - Watanabe H
FAU - Nagamachi, Y
AU  - Nagamachi Y
FAU - Niinaka, Y
AU  - Niinaka Y
FAU - Shiroishi, T
AU  - Shiroishi T
FAU - Ohwada, S
AU  - Ohwada S
FAU - Raz, A
AU  - Raz A
FAU - Yokota, J
AU  - Yokota J
LA  - eng
SI  - GENBANK/AA260491
SI  - GENBANK/AA479243
SI  - GENBANK/AF124144
SI  - GENBANK/AF124145
SI  - GENBANK/M62018
GR  - R0I-CA51714/CA/NCI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (DNA Primers)
RN  - 0 (DNA, Complementary)
RN  - 0 (Receptors, Cytokine)
RN  - EC 2.3.2.27 (AMFR protein, human)
RN  - EC 2.3.2.27 (Amfr protein, mouse)
RN  - EC 2.3.2.27 (Receptors, Autocrine Motility Factor)
RN  - EC 2.3.2.27 (Ubiquitin-Protein Ligases)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Caenorhabditis elegans/genetics
MH  - Chromosome Mapping
MH  - Cloning, Molecular
MH  - DNA Primers/genetics
MH  - DNA, Complementary/genetics
MH  - Gene Expression
MH  - Humans
MH  - Mice
MH  - Molecular Sequence Data
MH  - Molecular Weight
MH  - Receptors, Autocrine Motility Factor
MH  - Receptors, Cytokine/chemistry/*genetics
MH  - Sequence Homology, Amino Acid
MH  - Ubiquitin-Protein Ligases
EDAT- 1999/08/24 00:00
MHDA- 1999/08/24 00:01
CRDT- 1999/08/24 00:00
PHST- 1999/08/24 00:00 [pubmed]
PHST- 1999/08/24 00:01 [medline]
PHST- 1999/08/24 00:00 [entrez]
AID - S0014-5793(99)00966-7 [pii]
AID - 10.1016/s0014-5793(99)00966-7 [doi]
PST - ppublish
SO  - FEBS Lett. 1999 Aug 6;456(2):295-300. doi: 10.1016/s0014-5793(99)00966-7.