PMID- 10456317
OWN - NLM
STAT- MEDLINE
DCOM- 19990830
LR  - 20191210
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 456
IP  - 2
DP  - 1999 Aug 6
TI  - Identification of a novel gene of the X,K-ATPase beta-subunit family that is
      predominantly expressed in skeletal and heart muscles.
PG  - 243-8
AB  - We have identified the fifth member of the mammalian X,K-ATPase beta-subunit gene
      family. The human and rat genes are largely expressed in skeletal muscle and at a
      lower level in heart. The deduced human and rat proteins designated as
      beta(muscle) (beta(m)) consist of 357 and 356 amino acid residues, respectively, 
      and exhibit 89% identity. The sequence homology of beta(m) proteins with known
      Na,K- and H,K-ATPase beta-subunits are 30.5-39.4%. Unlike other beta-subunits,
      putative beta(m) proteins have large N-terminal cytoplasmic domains containing
      long Glu-rich sequences. The data obtained indicate the existence of hitherto
      unknown X,K-ATPase (most probably Na,K-ATPase) isozymes in muscle cells.
FAU - Pestov, N B
AU  - Pestov NB
AD  - Department of Pharmacology, Medical College of Ohio, Toledo 43614, USA.
FAU - Adams, G
AU  - Adams G
FAU - Shakhparonov, M I
AU  - Shakhparonov MI
FAU - Modyanov, N N
AU  - Modyanov NN
LA  - eng
SI  - GENBANK/AF015383
SI  - GENBANK/AF015384
SI  - GENBANK/AF015385
SI  - GENBANK/AF015386
GR  - GM-54997/GM/NIGMS NIH HHS/United States
GR  - HL-36573/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (DNA Primers)
RN  - 0 (DNA, Complementary)
RN  - 0 (Isoenzymes)
RN  - EC 3.6.3.10 (H(+)-K(+)-Exchanging ATPase)
RN  - EC 7.2.2.13 (Sodium-Potassium-Exchanging ATPase)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Animals, Newborn
MH  - Base Sequence
MH  - Conserved Sequence
MH  - DNA Primers/genetics
MH  - DNA, Complementary/genetics
MH  - Gene Expression
MH  - H(+)-K(+)-Exchanging ATPase/chemistry/*genetics
MH  - Humans
MH  - Isoenzymes/chemistry/*genetics
MH  - Molecular Sequence Data
MH  - *Multigene Family
MH  - Muscle, Skeletal/*enzymology
MH  - Myocardium/*enzymology
MH  - Protein Conformation
MH  - Rats
MH  - Sequence Homology, Amino Acid
MH  - Sodium-Potassium-Exchanging ATPase/chemistry/*genetics
MH  - Species Specificity
MH  - Tissue Distribution
EDAT- 1999/08/24 00:00
MHDA- 1999/08/24 00:01
CRDT- 1999/08/24 00:00
PHST- 1999/08/24 00:00 [pubmed]
PHST- 1999/08/24 00:01 [medline]
PHST- 1999/08/24 00:00 [entrez]
AID - S0014-5793(99)00954-0 [pii]
AID - 10.1016/s0014-5793(99)00954-0 [doi]
PST - ppublish
SO  - FEBS Lett. 1999 Aug 6;456(2):243-8. doi: 10.1016/s0014-5793(99)00954-0.