PMID- 10455148
OWN - NLM
STAT- MEDLINE
DCOM- 19990930
LR  - 20210209
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 274
IP  - 35
DP  - 1999 Aug 27
TI  - A novel oncostatin M-inducible gene OIG37 forms a gene family with MyD118 and
      GADD45 and negatively regulates cell growth.
PG  - 24766-72
AB  - Oncostatin M (OSM) is a member of the IL-6 family cytokines that use gp130 as a
      common signal transducer and exhibits both growth stimulatory as well as growth
      inhibitory activity depending on the cells. To analyze the mechanism of OSM
      function, we isolated immediate early responsive genes upon OSM stimulation. Here
      we describe the novel OSM-inducible gene OIG37 that is related to MyD118 and
      GADD45. The MyD118 gene has been described as an immediate early gene induced by 
      IL-6 in M1 monocytic cells, and GADD45 was identified as a gene induced by UV or 
      gamma-ray irradiation. Both are considered to function in growth arrest and/or
      DNA repair. Although the expression of OIG37, MyD118, and GADD45 was rather
      ubiquitous, it was differentially regulated. As the gp130 mutant defective for
      activating the STAT3 pathway showed the reduced induction of OIG37 by cytokine
      stimulation and expression of dominant negative STAT3 inhibited the induction of 
      OIG37 by OSM, STAT3 is involved in OIG37 induction by IL-6 family cytokines. To
      examine the function of OIG37, we expressed it in NIH3T3 and IL-3-dependent BaF3 
      cells and found that OIG37 suppressed cell growth without any evidence of
      apoptosis. Whereas both MyD118 and OIG37 suppressed cell growth in both cell
      lines, suppression by OIG37 was more efficient than by MyD118.
      Immunoprecipitation experiments indicated that OIG37 associates with p21, a
      cyclin-dependent kinase inhibitor, and proliferating cell nuclear antigen.
FAU - Nakayama, K
AU  - Nakayama K
AD  - Institute of Molecular and Cellular Biosciences, University of Tokyo, Bunkyo-ku, 
      Tokyo 113-0032, Japan.
FAU - Hara, T
AU  - Hara T
FAU - Hibi, M
AU  - Hibi M
FAU - Hirano, T
AU  - Hirano T
FAU - Miyajima, A
AU  - Miyajima A
LA  - eng
SI  - GENBANK/AB021884
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (Antigens, Differentiation)
RN  - 0 (Carrier Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (GADD45 protein)
RN  - 0 (GADD45G protein, human)
RN  - 0 (Gadd45b protein, mouse)
RN  - 0 (Gadd45g protein, mouse)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (OSM protein, human)
RN  - 0 (Osm protein, mouse)
RN  - 0 (Peptides)
RN  - 0 (Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Recombinant Fusion Proteins)
RN  - 106956-32-5 (Oncostatin M)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Antigens, Differentiation/chemistry/*genetics
MH  - Base Sequence
MH  - Carrier Proteins/chemistry/*genetics
MH  - Cell Division
MH  - Cell Line
MH  - Cloning, Molecular
MH  - DNA-Binding Proteins/chemistry/genetics
MH  - Gene Expression Regulation/drug effects
MH  - *Intracellular Signaling Peptides and Proteins
MH  - Mice
MH  - Molecular Sequence Data
MH  - Oncostatin M
MH  - Peptides/*pharmacology
MH  - Proteins/chemistry/*genetics
MH  - RNA, Messenger/metabolism
MH  - Recombinant Fusion Proteins/genetics
MH  - Sequence Alignment
MH  - Signal Transduction
MH  - Transcription, Genetic/genetics
MH  - Transfection
EDAT- 1999/08/24 00:00
MHDA- 1999/08/24 00:01
CRDT- 1999/08/24 00:00
PHST- 1999/08/24 00:00 [pubmed]
PHST- 1999/08/24 00:01 [medline]
PHST- 1999/08/24 00:00 [entrez]
AID - 10.1074/jbc.274.35.24766 [doi]
AID - S0021-9258(19)55414-X [pii]
PST - ppublish
SO  - J Biol Chem. 1999 Aug 27;274(35):24766-72. doi: 10.1074/jbc.274.35.24766.