PMID- 10454512
OWN - NLM
STAT- MEDLINE
DCOM- 19990921
LR  - 20131121
IS  - 0022-3565 (Print)
IS  - 0022-3565 (Linking)
VI  - 290
IP  - 3
DP  - 1999 Sep
TI  - Identification of quantitative trait loci for haloperidol-induced catalepsy on
      mouse chromosome 14.
PG  - 1337-46
AB  - Previous studies have established that neuroleptic-induced catalepsy in mice is a
      highly heritable trait. The current study focuses on the detection of
      quantitative trait loci (QTL) for haloperidol-induced catalepsy in a BALB/cJ x
      LP/J F(2) intercross. One thousand thirty-seven F(2) animals were phenotyped and 
      divided into four categories: very responsive (RR), responsive, nonresponsive,
      and very nonresponsive (NN). The RR and NN phenotypes comprised approximately 18%
      each of the total and differed in their haloperidol sensitivity by >10-fold. Sex 
      differed significantly between the NN and RR groups (chi(2) = 14.0; p <.0002);
      females comprised 58% of the RR individuals but only 38% of the NN individuals.
      The difference between the extreme phenotypes in the number of piebald animals
      was highly significant (chi(2) = 30, p <. 00001). Eight percent of the RR
      individuals were piebald compared with 30% of the NN individuals. A genome wide
      scan confirmed the presence of a QTL (peak LOD = 6.4) on chromosome 14 near the
      piebald (Ednrb) and 5-hydroxytryptamine(2A) (Htr2a) loci. Although the parental
      BALB/cJ and LP/J strains differed significantly in striatal
      5-hydroxytryptamine(2A) receptor binding, no marked differences were detected
      between the phenotypic extremes. A second QTL was detected on chromosome 14 (peak
      LOD = 6.9), which was located more proximally and included the Chat locus. No
      QTLs were detected on chromosomes 1 and 9, thus differentiating this cross from
      previous results obtained for a C57BL/6J x DBA/2J intercross.
FAU - Rasmussen, E
AU  - Rasmussen E
AD  - Department of Psychiatry and Psychology, State University of New York at Stony
      Brook, Stony Brook, New York, USA.
FAU - Cipp, L
AU  - Cipp L
FAU - Hitzemann, R
AU  - Hitzemann R
LA  - eng
GR  - MH-51372/MH/NIMH NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Pharmacol Exp Ther
JT  - The Journal of pharmacology and experimental therapeutics
JID - 0376362
RN  - 0 (Antipsychotic Agents)
RN  - J6292F8L3D (Haloperidol)
SB  - IM
MH  - Animals
MH  - Antipsychotic Agents/*toxicity
MH  - Catalepsy/*chemically induced/*genetics
MH  - Chromosome Mapping
MH  - Female
MH  - Genome
MH  - Genotype
MH  - Haloperidol/*toxicity
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Phenotype
MH  - *Quantitative Trait, Heritable
EDAT- 1999/08/24 00:00
MHDA- 1999/08/24 00:01
CRDT- 1999/08/24 00:00
PHST- 1999/08/24 00:00 [pubmed]
PHST- 1999/08/24 00:01 [medline]
PHST- 1999/08/24 00:00 [entrez]
PST - ppublish
SO  - J Pharmacol Exp Ther. 1999 Sep;290(3):1337-46.