PMID- 10450831
OWN - NLM
STAT- MEDLINE
DCOM- 19990915
LR  - 20090219
IS  - 0018-5043 (Print)
IS  - 0018-5043 (Linking)
VI  - 31
IP  - 7
DP  - 1999 Jul
TI  - Stanniocalcin 2: characterization of the protein and its localization to human
      pancreatic alpha cells.
PG  - 406-14
AB  - Stanniocalcin (STC) is a hormone that was originally identified in fish, where it
      inhibits calcium uptake by the gills and gut and stimulates phosphate adsorption 
      by the kidney. Recently, two mammalian homologues of stanniocalcin were
      identified. The first (STC1) shows 61% identity to the fish stanniocalcins and
      appears to have a function similar to that of the fish stanniocalcins. The second
      homologue (STC2) is 30-38% identical to the fish stanniocalcins, and is
      characterized by unique cysteine and histidine motifs that are not found in the
      other stanniocalcins. We purified both the native hamster and recombinant human
      STC2 proteins and obtained a partial amino acid sequence of the hamster protein. 
      Both proteins behave as a disulfide bonded homodimer, which undergoes
      post-translational modification(s). The STC2 gene was localized to human
      chromosome 5q35. Northern blot analysis revealed that the primary site of human
      STC2 production is the pancreas, and immunostaining localized the STC2 protein to
      a subpopulation of cells in the islet. Double immunostaining for STC2 and either 
      insulin or glucagon revealed that STC2 protein is found in the alpha cells, but
      not the beta cells. We speculate that STC2 may play a role in glucose
      homeostasis.
FAU - Moore, E E
AU  - Moore EE
AD  - ZymoGenetics, Inc., Seattle, WA, USA. mooreb@zgi.com
FAU - Kuestner, R E
AU  - Kuestner RE
FAU - Conklin, D C
AU  - Conklin DC
FAU - Whitmore, T E
AU  - Whitmore TE
FAU - Downey, W
AU  - Downey W
FAU - Buddle, M M
AU  - Buddle MM
FAU - Adams, R L
AU  - Adams RL
FAU - Bell, L A
AU  - Bell LA
FAU - Thompson, D L
AU  - Thompson DL
FAU - Wolf, A
AU  - Wolf A
FAU - Chen, L
AU  - Chen L
FAU - Stamm, M R
AU  - Stamm MR
FAU - Grant, F J
AU  - Grant FJ
FAU - Lok, S
AU  - Lok S
FAU - Ren, H
AU  - Ren H
FAU - De Jongh, K S
AU  - De Jongh KS
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Horm Metab Res
JT  - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et 
      metabolisme
JID - 0177722
RN  - 0 (Glycoproteins)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Recombinant Proteins)
RN  - 0 (STC2 protein, human)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Blotting, Northern
MH  - CHO Cells
MH  - Chromosome Mapping
MH  - Cricetinae
MH  - Glycoproteins/*analysis/chemistry/immunology
MH  - Humans
MH  - Immunohistochemistry
MH  - Intercellular Signaling Peptides and Proteins
MH  - Molecular Sequence Data
MH  - Pancreas/*chemistry
MH  - Recombinant Proteins/immunology
EDAT- 1999/08/18 00:00
MHDA- 1999/08/18 00:01
CRDT- 1999/08/18 00:00
PHST- 1999/08/18 00:00 [pubmed]
PHST- 1999/08/18 00:01 [medline]
PHST- 1999/08/18 00:00 [entrez]
AID - 10.1055/s-2007-978764 [doi]
PST - ppublish
SO  - Horm Metab Res. 1999 Jul;31(7):406-14. doi: 10.1055/s-2007-978764.