PMID- 10449921
OWN - NLM
STAT- MEDLINE
DCOM- 19991015
LR  - 20171101
IS  - 0301-0171 (Print)
IS  - 0301-0171 (Linking)
VI  - 85
IP  - 3-4
DP  - 1999
TI  - Cloning, characterization, and chromosome assignment of Zfp146 the mouse ortholog
      of human ZNF146, a gene amplified and overexpressed in pancreatic cancer, and
      Zfp260 a closely related gene.
PG  - 297-300
AB  - The human OZF gene (ZNF146), located in chromosome band 19q13.1, is amplified and
      overexpressed in pancreatic carcinomas. It encodes a protein consisting solely of
      ten Kruppel zinc finger motifs. We report here the isolation and the
      characterization of the murine OZF cDNA (Zfp146). Comparison of the deduced amino
      acid sequences between murine, human and bovine cDNAs revealed a strong identity 
      (95%). A closely related gene, Zfp260, was also isolated and characterized. It
      encodes a putative protein consisting of three vestigial zinc finger motifs
      followed by ten Kruppel zinc fingers sharing 79% identity and no gap insertion
      with the Zfp146 zinc fingers. In vitro transcription/translation of both genes
      led to synthesis of proteins of the predicted size. Co-expression was observed at
      the mRNA level in eight adult mouse tissues. Two-color FISH revealed
      co-localization of both genes on mouse chromosome 7 (band B1-B3). The
      co-expression and co-localization of Zfp146 and Zfp260 together with the close
      similarity of their zinc finger domains, suggests that both participate in the
      same regulatory pathway.
FAU - Blottiere, L
AU  - Blottiere L
AD  - Laboratoire d'Oncogenese, UMR147 CNRS, Institut Curie, Paris, France.
FAU - Apiou, F
AU  - Apiou F
FAU - Ferbus, D
AU  - Ferbus D
FAU - Guenzi, C
AU  - Guenzi C
FAU - Dutrillaux, B
AU  - Dutrillaux B
FAU - Prosperi, M T
AU  - Prosperi MT
FAU - Goubin, G
AU  - Goubin G
LA  - eng
SI  - GENBANK/AJ224763
SI  - GENBANK/AJ224805
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Cytogenet Cell Genet
JT  - Cytogenetics and cell genetics
JID - 0367735
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Kruppel-Like Transcription Factors)
RN  - 0 (RNA, Messenger)
RN  - 0 (RNA-Binding Proteins)
RN  - 0 (ZNF146 protein, human)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Blotting, Northern
MH  - Blotting, Southern
MH  - Blotting, Western
MH  - Chromosome Mapping
MH  - Chromosomes/genetics
MH  - Cloning, Molecular
MH  - DNA-Binding Proteins/biosynthesis/*genetics
MH  - Gene Amplification
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Kruppel-Like Transcription Factors
MH  - Mice
MH  - Mice, Inbred BALB C/*genetics
MH  - Molecular Sequence Data
MH  - Open Reading Frames/genetics
MH  - Organ Specificity/genetics
MH  - Pancreatic Neoplasms/*genetics
MH  - RNA, Messenger/biosynthesis
MH  - RNA-Binding Proteins/biosynthesis/*genetics
MH  - Sequence Analysis, DNA
MH  - Sequence Homology, Amino Acid
EDAT- 1999/08/18 00:00
MHDA- 1999/08/18 00:01
CRDT- 1999/08/18 00:00
PHST- 1999/08/18 00:00 [pubmed]
PHST- 1999/08/18 00:01 [medline]
PHST- 1999/08/18 00:00 [entrez]
AID - 15316 [pii]
AID - 10.1159/000015316 [doi]
PST - ppublish
SO  - Cytogenet Cell Genet. 1999;85(3-4):297-300. doi: 10.1159/000015316.