PMID- 10449920
OWN - NLM
STAT- MEDLINE
DCOM- 19991015
LR  - 20171101
IS  - 0301-0171 (Print)
IS  - 0301-0171 (Linking)
VI  - 85
IP  - 3-4
DP  - 1999
TI  - Coding region intron/exon organization, alternative splicing, and X-chromosome
      inactivation of the KRAB/FPB-domain-containing human zinc finger gene ZNF41.
PG  - 291-6
AB  - ZNF41 belongs to a cluster of human zinc finger genes residing within a gene-rich
      region at Xp11.23. ZNF41 encodes a KRAB/FPB (Kruppel-associated/finger preceding 
      box) domain, a potent transcription repression motif present in hundreds of
      vertebrate zinc finger protein genes, composed of two protein modules, A and B.
      Three introns, placed at identical positions in paralogous genes, interrupt four 
      exons encoding the ZNF41 N-terminal amino acids, the KRAB/FPB-A and KRAB/FPB-B
      modules, and the remaining coding region adjoined to the C-terminal zinc finger
      domain. Since the KRAB/FPB-A and KRAB/FPB-B modules are encoded by dedicated
      exons in ZNF41 and paralogous genes, exon skipping may lead to differential usage
      of these modules in alternative gene products. RT-PCR analysis of ZNF41 mRNAs
      showed that, while skipping of the KRAB/FPB-A and/or KRAB/FPB-B exons was not
      detected, the use of alternative donor/acceptor sites upstream of the KRAB/FPB-A 
      exon generates multiple ZNF41 transcripts potentially encoding polypeptides
      differing in the N-terminal region and expressed in different tissues. The
      expression pattern in cell hybrids containing either active or inactive X
      chromosomes indicates that ZNF41, which resides within a region of the X
      chromosome that includes genes that are both subject to and escape
      X-inactivation, is susceptible to X-chromosome inactivation.
FAU - Rosati, M
AU  - Rosati M
AD  - International Institute of Genetics and Biophysics, CNR, Naples, Italy.
FAU - Franze, A
AU  - Franze A
FAU - Matarazzo, M R
AU  - Matarazzo MR
FAU - Grimaldi, G
AU  - Grimaldi G
LA  - eng
SI  - GENBANK/AJ010017
SI  - GENBANK/AJ010018
SI  - GENBANK/AJ010019
SI  - GENBANK/AJ010020
SI  - GENBANK/AJ010021
SI  - GENBANK/AJ010022
SI  - GENBANK/AJ010023
SI  - GENBANK/X60155
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Cytogenet Cell Genet
JT  - Cytogenetics and cell genetics
JID - 0367735
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Kruppel-Like Transcription Factors)
RN  - 0 (RNA, Messenger)
RN  - 0 (ZNF41 protein, human)
SB  - IM
MH  - Alternative Splicing/*genetics
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - DNA-Binding Proteins/*genetics
MH  - *Dosage Compensation, Genetic
MH  - Gene Expression
MH  - Humans
MH  - Hybrid Cells
MH  - Kruppel-Like Transcription Factors
MH  - Molecular Sequence Data
MH  - Protein Structure, Tertiary
MH  - RNA, Messenger/biosynthesis
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Sequence Homology, Amino Acid
MH  - X Chromosome/genetics
MH  - Zinc Fingers/*genetics
EDAT- 1999/08/18 00:00
MHDA- 1999/08/18 00:01
CRDT- 1999/08/18 00:00
PHST- 1999/08/18 00:00 [pubmed]
PHST- 1999/08/18 00:01 [medline]
PHST- 1999/08/18 00:00 [entrez]
AID - 15315 [pii]
AID - 10.1159/000015315 [doi]
PST - ppublish
SO  - Cytogenet Cell Genet. 1999;85(3-4):291-6. doi: 10.1159/000015315.