PMID- 10449790
OWN - NLM
STAT- MEDLINE
DCOM- 19990909
LR  - 20190501
IS  - 0027-8424 (Print)
IS  - 0027-8424 (Linking)
VI  - 96
IP  - 17
DP  - 1999 Aug 17
TI  - theta, a novel gamma-aminobutyric acid type A receptor subunit.
PG  - 9891-6
AB  - gamma-Aminobutyric acid type A (GABA-A) receptors are a major mediator of
      inhibitory neurotransmission in the mammalian central nervous system, and the
      site of action of a number of clinically important drugs. These receptors exist
      as a family of subtypes with distinct temporal and spatial patterns of expression
      and distinct properties that presumably underlie a precise role for each subtype.
      The newest member of this gene family is the theta subunit. The deduced
      polypeptide sequence is 627 amino acids long and has highest sequence identity
      (50.5%) with the beta1 subunit. Within the rat striatum, this subunit coassembles
      with alpha2, beta1, and gamma1, suggesting that gamma-aminobutyric acid type A
      receptors consisting of arrangements other than alpha beta + gamma, delta, or
      epsilon do exist. Expression of alpha2beta1gamma1theta in transfected mammalian
      cells leads to the formation of receptors with a 4-fold decrease in the affinity 
      for gamma-aminobutyric acid compared with alpha2beta1gamma1. This subunit has a
      unique distribution, with studies so far suggesting significant expression within
      monoaminergic neurons of both human and monkey brain.
FAU - Bonnert, T P
AU  - Bonnert TP
AD  - Neuroscience Research Centre, Merck Sharp and Dohme Research Laboratories,
      Eastwick Road, Harlow, Essex CM20 2QR, England, UK.
FAU - McKernan, R M
AU  - McKernan RM
FAU - Farrar, S
AU  - Farrar S
FAU - le Bourdelles, B
AU  - le Bourdelles B
FAU - Heavens, R P
AU  - Heavens RP
FAU - Smith, D W
AU  - Smith DW
FAU - Hewson, L
AU  - Hewson L
FAU - Rigby, M R
AU  - Rigby MR
FAU - Sirinathsinghji, D J
AU  - Sirinathsinghji DJ
FAU - Brown, N
AU  - Brown N
FAU - Wafford, K A
AU  - Wafford KA
FAU - Whiting, P J
AU  - Whiting PJ
LA  - eng
SI  - GENBANK/AF144648
PT  - Journal Article
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Receptors, GABA-A)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Brain Chemistry
MH  - Haplorhini
MH  - Humans
MH  - Molecular Sequence Data
MH  - Oocytes/metabolism
MH  - Protein Conformation
MH  - Rats
MH  - Receptors, GABA-A/*genetics
MH  - Sequence Alignment
MH  - Transfection
MH  - Xenopus
PMC - PMC22306
EDAT- 1999/08/18 00:00
MHDA- 1999/08/18 00:01
CRDT- 1999/08/18 00:00
PHST- 1999/08/18 00:00 [pubmed]
PHST- 1999/08/18 00:01 [medline]
PHST- 1999/08/18 00:00 [entrez]
AID - 10.1073/pnas.96.17.9891 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9891-6. doi:
      10.1073/pnas.96.17.9891.