PMID- 10449787
OWN - NLM
STAT- MEDLINE
DCOM- 19990909
LR  - 20190501
IS  - 0027-8424 (Print)
IS  - 0027-8424 (Linking)
VI  - 96
IP  - 17
DP  - 1999 Aug 17
TI  - CoREST: a functional corepressor required for regulation of neural-specific gene 
      expression.
PG  - 9873-8
AB  - Several genes encoding proteins critical to the neuronal phenotype, such as the
      brain type II sodium channel gene, are expressed to high levels only in neurons. 
      This cell specificity is due, in part, to long-term repression in nonneural cells
      mediated by the repressor protein REST/NRSF (RE1 silencing transcription
      factor/neural-restrictive silencing factor). We show here that CoREST, a newly
      identified human protein, functions as a corepressor for REST. A single zinc
      finger motif in REST is required for CoREST interaction. Mutations of the motif
      that disrupt binding also abrogate repression. When fused to a Gal4 DNA-binding
      domain, CoREST functions as a repressor. CoREST is present in cell lines that
      express REST, and the proteins are found in the same immunocomplex. CoREST
      contains two SANT (SW13/ADA2/NCoR/TFIIIB B) domains, a structural feature of the 
      nuclear receptor and silencing mediator for retinoid and thyroid human receptors 
      (SMRT)-extended corepressors that mediate inducible repression by steroid hormone
      receptors. Together, REST and CoREST mediate repression of the type II sodium
      channel promoter in nonneural cells, and the REST/CoREST complex may mediate
      long-term repression essential to maintenance of cell identity.
FAU - Andres, M E
AU  - Andres ME
AD  - Howard Hughes Medical Institute and Department of Neurobiology and Behavior,
      State University of New York, Stony Brook, NY 11794, USA.
FAU - Burger, C
AU  - Burger C
FAU - Peral-Rubio, M J
AU  - Peral-Rubio MJ
FAU - Battaglioli, E
AU  - Battaglioli E
FAU - Anderson, M E
AU  - Anderson ME
FAU - Grimes, J
AU  - Grimes J
FAU - Dallman, J
AU  - Dallman J
FAU - Ballas, N
AU  - Ballas N
FAU - Mandel, G
AU  - Mandel G
LA  - eng
SI  - GENBANK/AF155595
GR  - R01 GM050224/GM/NIGMS NIH HHS/United States
GR  - R01 NS022518/NS/NINDS NIH HHS/United States
GR  - GM 502224-S1/GM/NIGMS NIH HHS/United States
GR  - NS25518/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Co-Repressor Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (RCOR1 protein, human)
RN  - 0 (RE1-silencing transcription factor)
RN  - 0 (Repressor Proteins)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Cells, Cultured
MH  - Co-Repressor Proteins
MH  - DNA-Binding Proteins/*physiology
MH  - *Gene Expression Regulation
MH  - Humans
MH  - Molecular Sequence Data
MH  - Nerve Tissue Proteins/chemistry/genetics/*physiology
MH  - Neurons/physiology
MH  - Rabbits
MH  - Repressor Proteins/chemistry/genetics/*physiology
MH  - *Transcription Factors
MH  - Transfection
MH  - *Zinc Fingers
PMC - PMC22303
EDAT- 1999/08/18 00:00
MHDA- 1999/08/18 00:01
CRDT- 1999/08/18 00:00
PHST- 1999/08/18 00:00 [pubmed]
PHST- 1999/08/18 00:01 [medline]
PHST- 1999/08/18 00:00 [entrez]
AID - 10.1073/pnas.96.17.9873 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9873-8. doi:
      10.1073/pnas.96.17.9873.