PMID- 10449773
OWN - NLM
STAT- MEDLINE
DCOM- 19990909
LR  - 20190501
IS  - 0027-8424 (Print)
IS  - 0027-8424 (Linking)
VI  - 96
IP  - 17
DP  - 1999 Aug 17
TI  - Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in
      the activation of myeloid cells.
PG  - 9792-6
AB  - Crosslinking of immunoreceptor tyrosine-based activation motif (ITAM)-containing 
      receptor complexes on a variety of cells leads to their activation through the
      sequential triggering of protein tyrosine kinases. Recently, DAP12 has been
      identified as an ITAM-bearing signaling molecule that is noncovalently associated
      with activating isoforms of MHC class I receptors on natural killer cells. In
      addition to natural killer cells, DAP12 is expressed in peripheral blood
      monocytes, macrophages, and dendritic cells, suggesting association with other
      receptors present in these cell types. In the present study, we report the
      molecular cloning of the myeloid DAP12-associating lectin-1 (MDL-1), a
      DAP12-associating membrane receptor expressed exclusively in monocytes and
      macrophages. MDL-1 is a type II transmembrane protein belonging to the C type
      lectin superfamily and contains a charged residue in the transmembrane region
      that enables it to pair with DAP12. Crosslinking of MDL-1/DAP12 complexes in J774
      mouse macrophage cells resulted in calcium mobilization. These findings suggest
      that signaling via MDL-1/DAP12 complexes may constitute a significant activation 
      pathway in myeloid cells.
FAU - Bakker, A B
AU  - Bakker AB
AD  - Department of Immunobiology, DNAX Research Institute of Cellular and Molecular
      Biology, 901 California Avenue, Palo Alto, CA 94304-1104, USA.
FAU - Baker, E
AU  - Baker E
FAU - Sutherland, G R
AU  - Sutherland GR
FAU - Phillips, J H
AU  - Phillips JH
FAU - Lanier, L L
AU  - Lanier LL
LA  - eng
SI  - GENBANK/AF139768
SI  - GENBANK/AF139769
SI  - GENBANK/AJ271684
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (CLEC5A protein, human)
RN  - 0 (Clec5a protein, mouse)
RN  - 0 (Lectins, C-Type)
RN  - 0 (Membrane Proteins)
RN  - 0 (Phosphoproteins)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (TYROBP protein, human)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Cell Line
MH  - Cloning, Molecular
MH  - Gene Expression Regulation
MH  - Killer Cells, Natural/*metabolism
MH  - *Lectins, C-Type
MH  - Macrophages/metabolism
MH  - Membrane Proteins
MH  - Mice
MH  - Molecular Sequence Data
MH  - Phosphoproteins/*metabolism
MH  - Receptors, Cell Surface/*genetics/*isolation & purification/metabolism
MH  - Receptors, Immunologic/*metabolism
MH  - Surface Properties
PMC - PMC22289
EDAT- 1999/08/18 00:00
MHDA- 1999/08/18 00:01
CRDT- 1999/08/18 00:00
PHST- 1999/08/18 00:00 [pubmed]
PHST- 1999/08/18 00:01 [medline]
PHST- 1999/08/18 00:00 [entrez]
AID - 10.1073/pnas.96.17.9792 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9792-6. doi:
      10.1073/pnas.96.17.9792.