PMID- 10448073
OWN - NLM
STAT- MEDLINE
DCOM- 19990923
LR  - 20061115
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 262
IP  - 1
DP  - 1999 Aug 19
TI  - Developmental expression of sarcoglycan gene products in cultured myocytes.
PG  - 88-93
AB  - The sarcoglycan complex consists of four membrane-spanning proteins and was shown
      to be exclusively distributed in striated muscles. In this study, we analyzed the
      pattern of expression of the mRNAs and proteins of the sarcoglycan subunits
      during cell differentiation in a culture of myocytes. All four sarcoglycan mRNAs 
      were detectable in proliferating cells, and expression of the alpha- and
      gamma-subunits was up-regulated by 20- and 50-fold following muscle cell fusion. 
      However, sarcoglycan proteins were scarcely detectable in proliferating cells and
      were first detected 2 days after the induction to be differentiated. The
      accumulation of the sarcoglycan protein subunits was accompanied by cell
      differentiation. The discrepancy between the expression of the mRNAs and proteins
      of the sarcoglycan subunits in proliferating cells may be ascribed to rapid
      degradation of the protein.
CI  - Copyright 1999 Academic Press.
FAU - Noguchi, S
AU  - Noguchi S
AD  - National Institute of Neuroscience, National Center of Neurology and Psychiatry, 
      Kodaira, Tokyo, 187-8502, Japan.
FAU - Wakabayashi, E
AU  - Wakabayashi E
FAU - Imamura, M
AU  - Imamura M
FAU - Yoshida, M
AU  - Yoshida M
FAU - Ozawa, E
AU  - Ozawa E
LA  - eng
SI  - GENBANK/AB024920
SI  - GENBANK/AB024921
SI  - GENBANK/AB024922
SI  - GENBANK/AB024923
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Carrier Proteins)
RN  - 0 (Cytoskeletal Proteins)
RN  - 0 (DAG1 protein, human)
RN  - 0 (Dystrophin)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (SSPN protein, human)
RN  - 0 (Sarcoglycans)
RN  - 0 (Sspn protein, mouse)
RN  - 0 (Utrn protein, mouse)
RN  - 0 (Utrophin)
RN  - 146888-27-9 (Dystroglycans)
SB  - IM
MH  - Animals
MH  - Carrier Proteins/genetics
MH  - Cell Differentiation
MH  - Cell Division
MH  - Cell Fusion
MH  - Cell Line
MH  - Cytoskeletal Proteins/*genetics/metabolism
MH  - Dystroglycans
MH  - Dystrophin/genetics/metabolism
MH  - *Gene Expression Regulation
MH  - Humans
MH  - Membrane Glycoproteins/*genetics/metabolism
MH  - Membrane Proteins/genetics/metabolism
MH  - Mice
MH  - Molecular Sequence Data
MH  - Muscles/*cytology/metabolism
MH  - *Neoplasm Proteins
MH  - Protein Processing, Post-Translational
MH  - RNA, Messenger/genetics/metabolism
MH  - Sarcoglycans
MH  - Sequence Homology, Amino Acid
MH  - Utrophin
EDAT- 1999/08/17 00:00
MHDA- 1999/08/17 00:01
CRDT- 1999/08/17 00:00
PHST- 1999/08/17 00:00 [pubmed]
PHST- 1999/08/17 00:01 [medline]
PHST- 1999/08/17 00:00 [entrez]
AID - 10.1006/bbrc.1999.1163 [doi]
AID - S0006-291X(99)91163-4 [pii]
PST - ppublish
SO  - Biochem Biophys Res Commun. 1999 Aug 19;262(1):88-93. doi:
      10.1006/bbrc.1999.1163.