PMID- 10448064
OWN - NLM
STAT- MEDLINE
DCOM- 19990923
LR  - 20131121
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 262
IP  - 1
DP  - 1999 Aug 19
TI  - Molecular cloning of Frizzled-10, a novel member of the Frizzled gene family.
PG  - 39-43
AB  - The Frizzled genes encode WNT receptors. Frizzled-10 (FZD10), a novel member of
      the Frizzled gene family, has been cloned and characterized. Nucleotide sequence 
      analysis showed that human FZD10 gene encodes a seven-transmembrane-receptor of
      581 amino acids, with the N-terminal cysteine-rich domain and the C-terminal
      Ser/Thr-Xxx-Val motif. Larger amounts of FZD10 mRNA, 4.0 kb in size, were
      detected in the placenta and fetal kidney, followed by fetal lung and brain. In
      adult brain, FZD10 mRNA was abundant in the cerebellum. Among cancer cell lines, 
      FZD10 was highly expressed in a cervical cancer cell line, HeLa S3, and
      moderately in a colon cancer cell line, SW480. The FZD10 gene was mapped to human
      chromosome 12q24.33. FZD10 shares 65.7% amino-acid identity with Frizzled-9
      (FZD9). FZD10 and FZD9 constitute a subfamily among the Frizzled genes.
CI  - Copyright 1999 Academic Press.
FAU - Koike, J
AU  - Koike J
AD  - Genetics Division, National Cancer Center Research Institute, Tsukiji 5-chome,
      Chuo-ku, Tokyo, 104-0045, Japan.
FAU - Takagi, A
AU  - Takagi A
FAU - Miwa, T
AU  - Miwa T
FAU - Hirai, M
AU  - Hirai M
FAU - Terada, M
AU  - Terada M
FAU - Katoh, M
AU  - Katoh M
LA  - eng
SI  - GENBANK/AB027464
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (DNA, Complementary)
RN  - 0 (FZD10 protein, human)
RN  - 0 (FZD3 protein, human)
RN  - 0 (Frizzled Receptors)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, G-Protein-Coupled)
RN  - K848JZ4886 (Cysteine)
SB  - IM
MH  - Adult
MH  - Amino Acid Sequence
MH  - Cerebellum/metabolism
MH  - Chromosomes, Human, Pair 12/genetics
MH  - Cloning, Molecular
MH  - Cysteine/genetics
MH  - DNA, Complementary/genetics
MH  - Female
MH  - Frizzled Receptors
MH  - Gene Expression
MH  - Genomic Library
MH  - Humans
MH  - Kidney/embryology/metabolism
MH  - Lung/embryology/metabolism
MH  - Molecular Sequence Data
MH  - *Multigene Family
MH  - Neoplasms/genetics
MH  - Phylogeny
MH  - Placenta/metabolism
MH  - RNA, Messenger/analysis/genetics
MH  - Receptors, Cell Surface/chemistry/*genetics
MH  - *Receptors, G-Protein-Coupled
MH  - Sequence Homology, Amino Acid
MH  - Tumor Cells, Cultured
EDAT- 1999/08/17 00:00
MHDA- 1999/08/17 00:01
CRDT- 1999/08/17 00:00
PHST- 1999/08/17 00:00 [pubmed]
PHST- 1999/08/17 00:01 [medline]
PHST- 1999/08/17 00:00 [entrez]
AID - 10.1006/bbrc.1999.1161 [doi]
AID - S0006-291X(99)91161-0 [pii]
PST - ppublish
SO  - Biochem Biophys Res Commun. 1999 Aug 19;262(1):39-43. doi:
      10.1006/bbrc.1999.1161.