PMID- 10446991
OWN - NLM
STAT- MEDLINE
DCOM- 19990907
LR  - 20151119
IS  - 0008-5472 (Print)
IS  - 0008-5472 (Linking)
VI  - 59
IP  - 15
DP  - 1999 Aug 1
TI  - Identification of a gene encoding a human oxysterol-binding protein-homologue: a 
      potential general molecular marker for blood dissemination of solid tumors.
PG  - 3748-53
AB  - This study describes a new potential role in human cancer for a gene, HLM,
      isolated by differential display, that bears homology to an oxysterol-binding
      protein. A significant association between increased expression of HLM with
      metastatic disease was found. HLM mRNA levels were increased in circulating tumor
      cells in patients' peripheral blood and in primary human epithelial cells
      expressing the human papillomavirus16 E6 and E7 proteins. HLM mRNA was not
      detected in most normal human tissues, including peripheral blood and lymph node.
      These findings indicate that HLM may function as a potential marker for tumor
      dissemination.
FAU - Fournier, M V
AU  - Fournier MV
AD  - Cell Growth and Regulation Division, Dana Farber Cancer Institute, Boston,
      Massachusetts 02115, USA. fournier@mbcrr.harvard.edu
FAU - Guimaraes da Costa, F
AU  - Guimaraes da Costa F
FAU - Paschoal, M E
AU  - Paschoal ME
FAU - Ronco, L V
AU  - Ronco LV
FAU - Carvalho, M G
AU  - Carvalho MG
FAU - Pardee, A B
AU  - Pardee AB
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (E6 protein, Human papillomavirus type 16)
RN  - 0 (Oncogene Proteins, Viral)
RN  - 0 (Papillomavirus E7 Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (RNA, Neoplasm)
RN  - 0 (Receptors, Steroid)
RN  - 0 (Repressor Proteins)
RN  - 0 (oncogene protein E7, Human papillomavirus type 16)
RN  - 0 (oxysterol binding protein)
SB  - IM
EIN - Cancer Res 2001 Jan 15;61(2):792. Guimaraes, FC [corrected to Guimaraes da Costa,
      F]
MH  - Amino Acid Sequence
MH  - Biomarkers, Tumor/blood/*genetics
MH  - Breast/cytology/metabolism
MH  - Breast Neoplasms/chemistry
MH  - Cell Line, Transformed
MH  - Cells, Cultured
MH  - Colonic Neoplasms/genetics/metabolism/pathology
MH  - Disease Progression
MH  - Epithelial Cells/metabolism
MH  - Gene Expression Regulation, Neoplastic
MH  - *Genes
MH  - HeLa Cells
MH  - Humans
MH  - Lung Neoplasms/blood
MH  - Molecular Sequence Data
MH  - Neoplasm Metastasis
MH  - *Neoplastic Cells, Circulating
MH  - Oncogene Proteins, Viral/physiology
MH  - Papillomaviridae/genetics
MH  - Papillomavirus E7 Proteins
MH  - RNA, Messenger/biosynthesis
MH  - RNA, Neoplasm/biosynthesis
MH  - Receptors, Steroid/blood/*genetics
MH  - *Repressor Proteins
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
EDAT- 1999/08/14 00:00
MHDA- 1999/08/14 00:01
CRDT- 1999/08/14 00:00
PHST- 1999/08/14 00:00 [pubmed]
PHST- 1999/08/14 00:01 [medline]
PHST- 1999/08/14 00:00 [entrez]
PST - ppublish
SO  - Cancer Res. 1999 Aug 1;59(15):3748-53.