PMID- 10446281
OWN - NLM
STAT- MEDLINE
DCOM- 19991104
LR  - 20190910
IS  - 0925-4773 (Print)
IS  - 0925-4773 (Linking)
VI  - 86
IP  - 1-2
DP  - 1999 Aug
TI  - Pmg-1 and pmg-2 constitute a novel family of KAP genes differentially expressed
      during skin and mammary gland development.
PG  - 193-6
AB  - The epidermis, by invagination of the undifferentiated ectodermal cells, gives
      rise to several distinct structures including hair, sebaceous, eccrine sweat and 
      mammary glands. We have recently isolated a novel gene, pmg-1, expressed in the
      pubertal mouse mammary gland. While investigating its genomic structure, we
      identified a related gene in close proximity, which we have termed pmg-2. pmg-1
      and pmg-2 are intron-less, are transcribed in opposite directions and are
      separated by a potential promoter region of 2.8 kb containing putative binding
      motifs for the developmental transcription factors Lef-1, Sox5 and D-STAT. pmg-1 
      and pmg-2 encode small proteins rich in G, S, F, Y and Q and contain
      characteristic repeats reminiscent of the keratin-associated proteins (KAPs).
      Both genes are expressed in growing hair follicles in skin as well as in
      sebaceous and eccrine sweat glands. Interestingly, expression is also detected in
      the mammary epithelium where it is limited to the onset of the pubertal growth
      phase and is independent of ovarian hormones. Their broad, developmentally
      controlled expression pattern, together with their unique amino acid composition,
      demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating
      in the differentiation of all epithelial cells forming the epidermal appendages.
FAU - Kuhn, F
AU  - Kuhn F
AD  - Department of Clinical Research, University of Berne, Tiefenaustrasse 120,
      CH-3004, Berne, Switzerland.
FAU - Lassing, C
AU  - Lassing C
FAU - Range, A
AU  - Range A
FAU - Mueller, M
AU  - Mueller M
FAU - Hunziker, T
AU  - Hunziker T
FAU - Ziemiecki, A
AU  - Ziemiecki A
FAU - Andres, A C
AU  - Andres AC
LA  - eng
SI  - GENBANK/AF162800
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Mech Dev
JT  - Mechanisms of development
JID - 9101218
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Intermediate Filament Proteins)
RN  - 0 (Keratins, Hair-Specific)
RN  - 0 (Krtap14 protein, mouse)
RN  - 0 (Krtap15 protein, mouse)
RN  - 0 (LEF1 protein, human)
RN  - 0 (Lef1 protein, mouse)
RN  - 0 (Lymphoid Enhancer-Binding Factor 1)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Proteins)
RN  - 0 (SOX5 protein, human)
RN  - 0 (SOXD Transcription Factors)
RN  - 0 (Sox5 protein, mouse)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Animals, Newborn
MH  - Binding Sites
MH  - DNA-Binding Proteins/genetics/metabolism
MH  - Female
MH  - *Gene Expression Regulation, Developmental
MH  - Humans
MH  - *Intermediate Filament Proteins
MH  - Keratins, Hair-Specific
MH  - Lymphoid Enhancer-Binding Factor 1
MH  - Mammary Glands, Animal/*growth & development/metabolism
MH  - Mice
MH  - Molecular Sequence Data
MH  - Nuclear Proteins/genetics/metabolism
MH  - Proteins/*genetics/immunology/metabolism
MH  - Puberty/genetics
MH  - SOXD Transcription Factors
MH  - Sequence Homology, Amino Acid
MH  - Skin/*growth & development/metabolism
MH  - Transcription Factors/genetics/metabolism
MH  - Transcription, Genetic
EDAT- 1999/08/14 00:00
MHDA- 1999/08/14 00:01
CRDT- 1999/08/14 00:00
PHST- 1999/08/14 00:00 [pubmed]
PHST- 1999/08/14 00:01 [medline]
PHST- 1999/08/14 00:00 [entrez]
AID - S092547739900115X [pii]
AID - 10.1016/s0925-4773(99)00115-x [doi]
PST - ppublish
SO  - Mech Dev. 1999 Aug;86(1-2):193-6. doi: 10.1016/s0925-4773(99)00115-x.