PMID- 10446041
OWN - NLM
STAT- MEDLINE
DCOM- 19990902
LR  - 20190619
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 285
IP  - 5430
DP  - 1999 Aug 13
TI  - Integrin signaling.
PG  - 1028-32
AB  - Cells reside in a protein network, the extracellular matrix (ECM), which they
      secrete and mold into the intercellular space. The ECM exerts profound control
      over cells. The effects of the matrix are primarily mediated by integrins, a
      family of cell surface receptors that attach cells to the matrix and mediate
      mechanical and chemical signals from it. These signals regulate the activities of
      cytoplasmic kinases, growth factor receptors, and ion channels and control the
      organization of the intracellular actin cytoskeleton. Many integrin signals
      converge on cell cycle regulation, directing cells to live or die, to
      proliferate, or to exit the cell cycle and differentiate.
FAU - Giancotti, F G
AU  - Giancotti FG
AD  - Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer
      Center, New York, NY 10021, USA. f-giancotti@ski.mskcc.org
FAU - Ruoslahti, E
AU  - Ruoslahti E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Integrins)
RN  - EC 2.7.- (Protein Kinases)
SB  - IM
SB  - S
MH  - Animals
MH  - Apoptosis
MH  - Cell Division
MH  - *Cell Physiological Phenomena
MH  - Cell Size
MH  - Cytoskeleton/metabolism
MH  - Extracellular Matrix/metabolism
MH  - Humans
MH  - Integrins/chemistry/*metabolism
MH  - Protein Kinases/metabolism
MH  - *Signal Transduction
RF  - 65
EDAT- 1999/08/14 00:00
MHDA- 1999/08/14 00:01
CRDT- 1999/08/14 00:00
PHST- 1999/08/14 00:00 [pubmed]
PHST- 1999/08/14 00:01 [medline]
PHST- 1999/08/14 00:00 [entrez]
AID - 7724 [pii]
AID - 10.1126/science.285.5430.1028 [doi]
PST - ppublish
SO  - Science. 1999 Aug 13;285(5430):1028-32. doi: 10.1126/science.285.5430.1028.