PMID- 10445035
OWN - NLM
STAT- MEDLINE
DCOM- 19990830
LR  - 20190915
IS  - 1097-2765 (Print)
IS  - 1097-2765 (Linking)
VI  - 4
IP  - 1
DP  - 1999 Jul
TI  - JIL-1: a novel chromosomal tandem kinase implicated in transcriptional regulation 
      in Drosophila.
PG  - 129-35
AB  - We have cloned and characterized JIL-1, a novel tandem kinase in Drosophila that 
      associates with the chromosomes throughout the cell cycle. Antibody staining and 
      live imaging of JIL-1-GFP transgenic flies show that JIL-1 localizes to the 
      gene-rich interband regions of larval polytene chromosomes and is upregulated 
      almost 2-fold on the hypertranscribed male X chromosome compared to autosomes. 
      Phylogenetic analysis suggests that JIL-1 together with human MSKs defines a 
      separate family of tandem kinases. That JIL-1 is a functional kinase was 
      demonstrated by autophosphorylation and phosphorylation of histone H3 in vitro. 
      Based on these findings, we propose that JIL-1 may play a role in transcriptional 
      control potentially by regulating chromatin structure.
FAU - Jin, Y
AU  - Jin Y
AD  - Department of Zoology and Genetics, Iowa State University, Ames 50011, USA.
FAU - Wang, Y
AU  - Wang Y
FAU - Walker, D L
AU  - Walker DL
FAU - Dong, H
AU  - Dong H
FAU - Conley, C
AU  - Conley C
FAU - Johansen, J
AU  - Johansen J
FAU - Johansen, K M
AU  - Johansen KM
LA  - eng
SI  - GENBANK/AF142061
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Mol Cell
JT  - Molecular cell
JID - 9802571
RN  - 0 (Chromatin)
RN  - 0 (Chromosomal Proteins, Non-Histone)
RN  - 0 (Histones)
RN  - 0 (Insect Proteins)
RN  - EC 2.7.- (Protein Kinases)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Animals, Genetically Modified
MH  - Cell Cycle
MH  - Chromatin/chemistry
MH  - Chromosomal Proteins, Non-Histone/chemistry/*genetics
MH  - Cloning, Molecular
MH  - Drosophila/embryology/*enzymology
MH  - Gene Expression Regulation
MH  - Histones/metabolism
MH  - Humans
MH  - Insect Proteins/chemistry/genetics
MH  - Male
MH  - Molecular Sequence Data
MH  - Phylogeny
MH  - Protein Kinases/chemistry/*genetics
MH  - Salivary Glands/enzymology
MH  - X Chromosome/genetics
EDAT- 1999/08/13 00:00
MHDA- 1999/08/13 00:01
CRDT- 1999/08/13 00:00
PHST- 1999/08/13 00:00 [pubmed]
PHST- 1999/08/13 00:01 [medline]
PHST- 1999/08/13 00:00 [entrez]
AID - S1097-2765(00)80195-1 [pii]
AID - 10.1016/s1097-2765(00)80195-1 [doi]
PST - ppublish
SO  - Mol Cell. 1999 Jul;4(1):129-35. doi: 10.1016/s1097-2765(00)80195-1.