PMID- 10444591
OWN - NLM
STAT- MEDLINE
DCOM- 19990907
LR  - 20200311
IS  - 0890-9369 (Print)
IS  - 0890-9369 (Linking)
VI  - 13
IP  - 15
DP  - 1999 Aug 1
TI  - Analysis of the NuRD subunits reveals a histone deacetylase core complex and a
      connection with DNA methylation.
PG  - 1924-35
AB  - ATP-dependent nucleosome remodeling and core histone acetylation and
      deacetylation represent mechanisms to alter nucleosome structure. NuRD is a
      multisubunit complex containing nucleosome remodeling and histone deacetylase
      activities. The histone deacetylases HDAC1 and HDAC2 and the histone binding
      proteins RbAp48 and RbAp46 form a core complex shared between NuRD and
      Sin3-histone deacetylase complexes. The histone deacetylase activity of the core 
      complex is severely compromised. A novel polypeptide highly related to the
      metastasis-associated protein 1, MTA2, and the methyl-CpG-binding
      domain-containing protein, MBD3, were found to be subunits of the NuRD complex.
      MTA2 modulates the enzymatic activity of the histone deacetylase core complex.
      MBD3 mediates the association of MTA2 with the core histone deacetylase complex. 
      MBD3 does not directly bind methylated DNA but is highly related to MBD2, a
      polypeptide that binds to methylated DNA and has been reported to possess
      demethylase activity. MBD2 interacts with the NuRD complex and directs the
      complex to methylated DNA. NuRD may provide a means of gene silencing by DNA
      methylation.
FAU - Zhang, Y
AU  - Zhang Y
AD  - Howard Hughes Medical Institute (HHMI), Division of Nucleic Acids Enzymology,
      Department of Biochemistry, University of Medicine and Dentistry of New Jersey,
      Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA.
FAU - Ng, H H
AU  - Ng HH
FAU - Erdjument-Bromage, H
AU  - Erdjument-Bromage H
FAU - Tempst, P
AU  - Tempst P
FAU - Bird, A
AU  - Bird A
FAU - Reinberg, D
AU  - Reinberg D
LA  - eng
SI  - GENBANK/AF159259
GR  - WT_/Wellcome Trust/United Kingdom
GR  - F32 GM019515/GM/NIGMS NIH HHS/United States
GR  - GM-48518/GM/NIGMS NIH HHS/United States
GR  - 1F32GM19515-01/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genes Dev
JT  - Genes & development
JID - 8711660
RN  - 0 (Autoantigens)
RN  - 0 (CHD4 protein, human)
RN  - 0 (Carrier Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (MBD2 protein)
RN  - 0 (MBD3 protein, human)
RN  - 0 (Mbd3 protein, mouse)
RN  - 0 (Multienzyme Complexes)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Nucleosomes)
RN  - 0 (RBBP4 protein, human)
RN  - 0 (RBBP7 protein, human)
RN  - 0 (Rbbp4 protein, mouse)
RN  - 0 (Recombinant Fusion Proteins)
RN  - 0 (Repressor Proteins)
RN  - 0 (Retinoblastoma-Binding Protein 4)
RN  - 0 (Retinoblastoma-Binding Protein 7)
RN  - 0 (Transcription Factors)
RN  - 9007-49-2 (DNA)
RN  - EC 3.5.1.- (MTA2 protein, human)
RN  - EC 3.5.1.98 (HDAC1 protein, human)
RN  - EC 3.5.1.98 (Hdac2 protein, mouse)
RN  - EC 3.5.1.98 (Histone Deacetylase 1)
RN  - EC 3.5.1.98 (Histone Deacetylase 2)
RN  - EC 3.5.1.98 (Histone Deacetylases)
RN  - EC 3.5.1.98 (Mi-2 Nucleosome Remodeling and Deacetylase Complex)
RN  - EC 3.6.1.- (Adenosine Triphosphatases)
RN  - EC 3.6.4.- (DNA Helicases)
SB  - IM
MH  - *Adenosine Triphosphatases
MH  - Amino Acid Sequence
MH  - Autoantigens/isolation & purification/metabolism
MH  - Base Sequence
MH  - Carrier Proteins/chemistry/genetics/isolation & purification/*metabolism
MH  - Cloning, Molecular
MH  - DNA/chemistry/genetics/metabolism
MH  - *DNA Helicases
MH  - *DNA Methylation
MH  - DNA-Binding Proteins/chemistry/genetics/isolation & purification/*metabolism
MH  - HeLa Cells
MH  - Histone Deacetylase 1
MH  - Histone Deacetylase 2
MH  - Histone Deacetylases/chemistry/genetics/isolation & purification/*metabolism
MH  - Humans
MH  - Mi-2 Nucleosome Remodeling and Deacetylase Complex
MH  - Molecular Sequence Data
MH  - Multienzyme Complexes/*chemistry/genetics/isolation & purification/metabolism
MH  - Nuclear Proteins/isolation & purification/metabolism
MH  - Nucleosomes/chemistry/genetics/*metabolism
MH  - Protein Binding
MH  - Recombinant Fusion Proteins/isolation & purification/metabolism
MH  - *Repressor Proteins
MH  - Retinoblastoma-Binding Protein 4
MH  - Retinoblastoma-Binding Protein 7
MH  - Sequence Homology, Amino Acid
MH  - Transcription Factors
PMC - PMC316920
EDAT- 1999/08/13 00:00
MHDA- 1999/08/13 00:01
CRDT- 1999/08/13 00:00
PHST- 1999/08/13 00:00 [pubmed]
PHST- 1999/08/13 00:01 [medline]
PHST- 1999/08/13 00:00 [entrez]
AID - 10.1101/gad.13.15.1924 [doi]
PST - ppublish
SO  - Genes Dev. 1999 Aug 1;13(15):1924-35. doi: 10.1101/gad.13.15.1924.