PMID- 10441738 OWN - NLM STAT- MEDLINE DCOM- 19990923 LR - 20190905 IS - 0938-8990 (Print) IS - 0938-8990 (Linking) VI - 10 IP - 9 DP - 1999 Sep TI - Nucleotide sequences of the mouse globin beta gene cDNAs in a wild derived new haplotype Hbb(w1). PG - 879-82 AB - Haplotypes of the beta-globin gene complex (Hbb) in laboratory mice have been defined as d, p, and s. We previously found a new haplotype w1 in wild mice collected from northwestern China. This study analyzed the nucleotide sequences of b1 and b2-globin gene cDNAs of both the p and w1 haplotypes, in comparison with those of the d haplotype. In Hbb-b1 cDNA, six base substitutions were found between the d and w1 haplotypes and also between p and w1, but none existed between d and p. In Hbb-b2 cDNA, three base substitutions were found between the d and w1 haplotypes and also between d and p, but none between p and w1. This result indicated that the Hbb gene complex of the p haplotype carries b1(d) and b2(w1) genes and is probably a recombinant between d and w1 haplotypes. The hemoglobin containing the W1 phenotype showed oxygen-binding properties identical with those of the hemoglobins containing D and P phenotypes. FAU - Ueda, Y AU - Ueda Y AD - Laboratory of Animal Cell Technology, Fukuyama University, Fukuyama, Hiroshima-ken, 729-0292, Japan. FAU - Miyashita, N AU - Miyashita N FAU - Imai, K AU - Imai K FAU - Yamaguchi, Y AU - Yamaguchi Y FAU - Takamura, K AU - Takamura K FAU - Notohara, M AU - Notohara M FAU - Shiroishi, T AU - Shiroishi T FAU - Kawashima, T AU - Kawashima T FAU - Ning, L AU - Ning L FAU - Wang, C AU - Wang C FAU - Wu, X AU - Wu X FAU - Moriwaki, K AU - Moriwaki K LA - eng SI - GENBANK/AB020013 SI - GENBANK/AB020014 SI - GENBANK/AB020015 SI - GENBANK/AB020016 SI - GENBANK/AB020017 PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Mamm Genome JT - Mammalian genome : official journal of the International Mammalian Genome Society JID - 9100916 RN - 0 (DNA Primers) RN - 0 (DNA, Complementary) RN - 0 (Hemoglobins) RN - 9004-22-2 (Globins) RN - S88TT14065 (Oxygen) SB - IM MH - Animals MH - Animals, Wild MH - Asia MH - Base Sequence MH - DNA Primers/genetics MH - DNA, Complementary/*genetics MH - Globins/*genetics/metabolism MH - Haplotypes MH - Hemoglobins/genetics/metabolism MH - Mice MH - Mice, Congenic MH - Mice, Inbred BALB C MH - Mice, Inbred Strains MH - Molecular Sequence Data MH - Oxygen/blood MH - Sequence Homology, Nucleic Acid EDAT- 1999/08/12 00:00 MHDA- 1999/08/12 00:01 CRDT- 1999/08/12 00:00 PHST- 1999/08/12 00:00 [pubmed] PHST- 1999/08/12 00:01 [medline] PHST- 1999/08/12 00:00 [entrez] AID - MG99-633 [pii] AID - 10.1007/s003359901107 [doi] PST - ppublish SO - Mamm Genome. 1999 Sep;10(9):879-82. doi: 10.1007/s003359901107.