PMID- 10441735
OWN - NLM
STAT- MEDLINE
DCOM- 19990923
LR  - 20190905
IS  - 0938-8990 (Print)
IS  - 0938-8990 (Linking)
VI  - 10
IP  - 9
DP  - 1999 Sep
TI  - Physical mapping of the autoimmune disease susceptibility locus, Bphs:
      co-localization with a cluster of genes from the TNF receptor superfamily on
      mouse chromosome 6.
PG  - 858-63
AB  - An important approach to understanding complex diseases is to reduce them into
      well-characterized subphenotypes that are under monogenic control. One such
      example is Bordetella pertussis toxin-induced histamine sensitization in mice, a 
      subphenotype of experimental allergic encephalomyelitis and experimental allergic
      orchitis. This subphenotype is controlled by a single locus, Bphs, previously
      mapped to a 33 cM region on mouse Chromosome (Chr) 6. We achieved considerable
      reduction of this candidate region and constructed a YAC contig across the
      refined interval. Our results demonstrate that Bphs is located between D6Mit151
      and a newly developed marker, EC108RR, a region containing a small cluster of
      genes belonging to the TNF receptor superfamily. Sequence and quantitative
      analysis of the candidate gene, tumor necrosis factor receptor 1 (Tnfr1, p55),
      indicates that it is unlikely to be Bphs. However, the location of Bphs, together
      with physiologic effects it shares with Tnfr1 activation, suggest that Bphs may
      prove to be another member of the TNF receptor superfamily.
FAU - Meeker, N D
AU  - Meeker ND
AD  - Department of Veterinary Pathobiology, 2001 South Lincoln Ave., University of
      Illinois at Urbana-Champaign, Urbana, Illinois 61802, USA.
FAU - Stafford, A N
AU  - Stafford AN
FAU - Lunceford, J K
AU  - Lunceford JK
FAU - Avner, P
AU  - Avner P
FAU - Ma, R Z
AU  - Ma RZ
FAU - Teuscher, C
AU  - Teuscher C
LA  - eng
GR  - AI41747/AI/NIAID NIH HHS/United States
GR  - AI43521/AI/NIAID NIH HHS/United States
GR  - NS36526/NS/NINDS NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Mamm Genome
JT  - Mammalian genome : official journal of the International Mammalian Genome Society
JID - 9100916
RN  - 0 (Genetic Markers)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Virulence Factors, Bordetella)
RN  - EC 2.4.2.31 (Pertussis Toxin)
SB  - IM
MH  - Animals
MH  - Autoimmune Diseases/*genetics
MH  - Chromosomes, Artificial, Yeast/genetics
MH  - Encephalomyelitis, Autoimmune, Experimental/genetics
MH  - Genetic Markers
MH  - Histamine Release/drug effects/genetics
MH  - Male
MH  - Mice
MH  - Mice, Inbred C3H
MH  - Mice, Inbred CBA
MH  - *Multigene Family
MH  - Orchitis/genetics/immunology
MH  - Pertussis Toxin
MH  - Physical Chromosome Mapping
MH  - Polymorphism, Genetic
MH  - RNA, Messenger/analysis/genetics
MH  - Receptors, Tumor Necrosis Factor/*genetics
MH  - Recombination, Genetic
MH  - Virulence Factors, Bordetella/toxicity
EDAT- 1999/08/12 00:00
MHDA- 1999/08/12 00:01
CRDT- 1999/08/12 00:00
PHST- 1999/08/12 00:00 [pubmed]
PHST- 1999/08/12 00:01 [medline]
PHST- 1999/08/12 00:00 [entrez]
AID - MG99-SB91 [pii]
AID - 10.1007/s003359901104 [doi]
PST - ppublish
SO  - Mamm Genome. 1999 Sep;10(9):858-63. doi: 10.1007/s003359901104.